| 2021-08-28 | VicenzavFrosinoneSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-08-28 | Yeni MalatyasporvGaziantepSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-08-28 | WokingvHalifaxNational League · England | 2–3 | National League · England |
| 2021-08-28 | SochauxvGrenobleLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-08-28 | Forest GreenvPort ValeLeague Two · England | 0–2 | League Two · England |
| 2021-08-28 | Pau FCvDijonLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-08-28 | QPRvCoventryChampionship · England | 2–0 | Championship · England |
| 2021-08-28 | LaziovSpeziaSerie A · Italy | 6–1 | Serie A · Italy |
| 2021-08-28 | Din. BucurestivFC ArgesSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-08-28 | MotherwellvDundeePremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-08-28 | NimesvCaenLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-08-28 | Willem IIvZwolleEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-08-28 | NancyvAuxerreLigue 2 · France | 1–4 | Ligue 2 · France |
| 2021-08-28 | NorwichvLeicesterPremier League · England | 1–2 | Premier League · England |
| 2021-08-28 | Gamba OsakavCerezo OsakaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-08-28 | FalkirkvQueens ParkLeague One · Scotland | 0–1 | League One · Scotland |
| 2021-08-28 | Sport RecifevChapecoense-SCSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-08-28 | CeltavAth BilbaoLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-08-28 | Hokkaido Consadole SapporovKawasaki FrontaleJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-08-28 | BrannvHaugesundEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-08-28 | Guadalajara ChivasvNecaxaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-08-28 | Milton Keynes DonsvAccringtonLeague One · England | 2–0 | League One · England |
| 2021-08-28 | KilmarnockvInverness CChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-08-28 | HataysporvAlanyasporSüper Lig · Turkey | 5–0 | Süper Lig · Turkey |
| 2021-08-28 | Termalica B-B.vCracoviaEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-08-28 | PonferradinavGironaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-08-28 | A. KlagenfurtvTirolBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-08-28 | MiddlesbroughvBlackburnChampionship · England | 1–1 | Championship · England |
| 2021-08-28 | Lech PoznanvPogon SzczecinEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-08-28 | MorecambevSheffield WedsLeague One · England | 1–0 | League One · England |
| 2021-08-28 | EastleighvWrexhamNational League · England | 0–2 | National League · England |
| 2021-08-28 | Vissel KobevFC TokyoJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-08-28 | ElchevSevillaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-08-28 | MontrosevDumbartonLeague One · Scotland | 1–2 | League One · Scotland |
| 2021-08-28 | East FifevPeterheadLeague One · Scotland | 3–0 | League One · Scotland |
| 2021-08-28 | Lechia GdanskvRadomiak RadomEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-08-28 | ForfarvStranraerLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-08-28 | MaidenheadvDover AthleticNational League · England | 2–0 | National League · England |
| 2021-08-28 | Leyton OrientvBradfordLeague Two · England | 2–0 | League Two · England |
| 2021-08-28 | SantosvFlamengo RJSerie A · Brazil | 0–4 | Serie A · Brazil |
| 2021-08-28 | AltachvWolfsberger ACBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2021-08-28 | BuyuksehyrvKayserisporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-08-28 | Crawley TownvNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2021-08-28 | HartbergvSalzburgBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-08-28 | StuttgartvFreiburgBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-08-28 | Queen of SthvHamiltonChampionship · Scotland | 1–2 | Championship · Scotland |
| 2021-08-27 | River PlatevAldosiviLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-08-27 | AntalyasporvRizesporSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2021-08-27 | BelenensesvMoreirensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-08-27 | PisavAlessandriaSerie B · Italy | 2–0 | Serie B · Italy |