| 2021-08-28 | Bayern MunichvHerthaBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2021-08-28 | CF MontrealvToronto FCMLS · United States | 3–1 | MLS · United States |
| 2021-08-28 | PortovAroucaPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-08-28 | DerbyvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2021-08-28 | FiorentinavTorinoSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-08-28 | NiortvAmiensLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-08-28 | Mazatlan FCvAtl. San LuisLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-08-28 | BastiavLe HavreLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-08-28 | RodezvDunkerqueLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-08-28 | Atlanta UtdvNashville SCMLS · United States | 0–2 | MLS · United States |
| 2021-08-28 | DegerforsvMjallbyAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2021-08-28 | SuttonvOldhamLeague Two · England | 1–2 | League Two · England |
| 2021-08-28 | FC Rapid BucurestivUniv. CraiovaSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-08-28 | HeidenheimvHamburg2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-08-28 | ChesterfieldvWealdstoneNational League · England | 2–0 | National League · England |
| 2021-08-28 | FC KolnvBochumBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-08-28 | JuventusvEmpoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-08-28 | OxfordvLincolnLeague One · England | 3–1 | League One · England |
| 2021-08-28 | FulhamvStokeChampionship · England | 3–0 | Championship · England |
| 2021-08-28 | GuingampvAjaccioLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-08-28 | GrimsbyvWeymouthNational League · England | 1–0 | National League · England |
| 2021-08-28 | Sp GijonvMirandesLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-08-28 | CharltonvCreweLeague One · England | 2–0 | League One · England |
| 2021-08-28 | CambridgevBoltonLeague One · England | 1–0 | League One · England |
| 2021-08-28 | LeganesvIbizaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-08-28 | Club TijuanavMonterreyLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-08-28 | LutonvSheffield UnitedChampionship · England | 0–0 | Championship · England |
| 2021-08-28 | Cercle BruggevSt TruidenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-08-28 | PeterborovWest BromChampionship · England | 0–1 | Championship · England |
| 2021-08-28 | AC OuluvLahtiVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2021-08-28 | Sanfrecce HiroshimavOita TrinitaJ1 League · Japan | 4–1 | J1 League · Japan |
| 2021-08-28 | MarseillevSt EtienneLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-08-28 | Holstein KielvErzgebirge Aue2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-08-28 | Quevilly RouenvParis FCLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-08-28 | Orlando CityvInter MiamiMLS · United States | 0–0 | MLS · United States |
| 2021-08-28 | HartlepoolvCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-08-28 | St. GilloisevStandardPro League · Belgium | 4–0 | Pro League · Belgium |
| 2021-08-28 | BesiktasvKaragumrukSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-08-28 | HonkavHIFKVeikkausliiga · Finland | 0–3 | Veikkausliiga · Finland |
| 2021-08-28 | BarnsleyvBirminghamChampionship · England | 1–1 | Championship · England |
| 2021-08-28 | LiverpoolvChelseaPremier League · England | 1–1 | Premier League · England |
| 2021-08-28 | AugsburgvLeverkusenBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2021-08-28 | YeovilvKings LynnNational League · England | 1–2 | National League · England |
| 2021-08-28 | Schalke 04vFortuna Dusseldorf2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-08-28 | HarrogatevExeterLeague Two · England | 1–1 | League Two · England |
| 2021-08-28 | EupenvSeraingPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-08-28 | PrestonvSwanseaChampionship · England | 3–1 | Championship · England |
| 2021-08-28 | RotherhamvDoncasterLeague One · England | 2–0 | League One · England |
| 2021-08-28 | WalsallvStevenageLeague Two · England | 1–0 | League Two · England |
| 2021-08-28 | West HamvCrystal PalacePremier League · England | 2–2 | Premier League · England |