| 2021-08-29 | AltayvFenerbahceSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-08-29 | Wisla PlockvRakowEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-08-29 | BurnleyvLeedsPremier League · England | 1–1 | Premier League · England |
| 2021-08-29 | AdmiravSturm GrazBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-08-29 | ParmavBeneventoSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-08-29 | PalmeirasvAthletico-PRSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-08-29 | Sp BragavGuimaraesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-08-29 | Sporting Kansas CityvColorado RapidsMLS · United States | 1–1 | MLS · United States |
| 2021-08-29 | PortimonensevPacos FerreiraPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-08-29 | AberdeenvRoss CountyPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-08-29 | LillevMontpellierLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-08-29 | ZaglebievSlask WroclawEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-08-29 | MilanvCagliariSerie A · Italy | 4–1 | Serie A · Italy |
| 2021-08-29 | Shonan BellmarevUrawa RedsJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-08-29 | GremiovCorinthiansSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-08-29 | TottenhamvWatfordPremier League · England | 1–0 | Premier League · England |
| 2021-08-29 | SivassporvGoztepSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-08-29 | AjaxvVitesseEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-08-29 | LensvLorientLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-08-29 | HJKvKuPSVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2021-08-29 | NorrkopingvOstersundsAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-08-29 | OostendevWaregemPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-08-29 | Troyesv MonacoLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-08-29 | VikingvRosenborgEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-08-29 | AngersvRennesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-08-29 | Arsenal SarandivDefensa y JusticiaLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-08-29 | LugovValladolidLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-08-29 | MariehamnvIlvesVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2021-08-29 | GrasshoppersvServetteSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-08-29 | Sarpsborg 08vSandefjordEliteserien · Norway | 5–0 | Eliteserien · Norway |
| 2021-08-29 | SiriusvDjurgardenAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-08-29 | TolucavUNAM PumasLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-08-29 | CadizvOsasunaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2021-08-29 | HammarbyvMalmo FFAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-08-29 | Velez SarsfieldvGodoy CruzLiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-08-29 | America MGvCearaSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-08-29 | TromsovBodo/GlimtEliteserien · Norway | 2–3 | Eliteserien · Norway |
| 2021-08-29 | BarcelonavGetafeLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-08-29 | Avispa FukuokavTokushimaJ1 League · Japan | 3–0 | J1 League · Japan |
| 2021-08-29 | New York CityvNew England RevolutionMLS · United States | 2–0 | MLS · United States |
| 2021-08-29 | VejlevFC CopenhagenSuperliga · Denmark | 0–4 | Superliga · Denmark |
| 2021-08-29 | RangersvCelticPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-08-29 | ReimsvParis SGLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-08-28 | Aston VillavBrentfordPremier League · England | 1–1 | Premier League · England |
| 2021-08-28 | PerugiavAscoliSerie B · Italy | 2–3 | Serie B · Italy |
| 2021-08-28 | DarmstadtvHannover2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-08-28 | PueblavQueretaroLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-08-28 | CowdenbeathvAnnan AthleticLeague Two · Scotland | 1–3 | League Two · Scotland |
| 2021-08-28 | HuddersfieldvReadingChampionship · England | 4–0 | Championship · England |
| 2021-08-28 | CambuurvTwenteEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |