| 2010-04-11 | NancyvAuxerreLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-04-11 | LeixoesvPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2010-04-11 | CartagenavMurciaLaLiga 2 · Spain | 3–2 | LaLiga 2 · Spain |
| 2010-04-11 | BolognavLazioSerie A · Italy | 2–3 | Serie A · Italy |
| 2010-04-11 | PanathinaikosvIraklisSuper League Greece · Greece | 2–0 | Super League Greece · Greece |
| 2010-04-11 | PanioniosvLarisaSuper League Greece · Greece | 0–3 | Super League Greece · Greece |
| 2010-04-11 | KasimpasavAnkaragucuSüper Lig · Türkiye | 2–0 | Süper Lig · Türkiye |
| 2010-04-11 | DenizlisporvEskisehirsporSüper Lig · Türkiye | 1–0 | Süper Lig · Türkiye |
| 2010-04-11 | MilanvCataniaSerie A · Italy | 2–2 | Serie A · Italy |
| 2010-04-11 | CastellonvCeltaLaLiga 2 · Spain | 2–1 | LaLiga 2 · Spain |
| 2010-04-11 | OsasunavZaragozaLaLiga · Spain | 2–0 | LaLiga · Spain |
| 2010-04-11 | PanthrakikosvOlympiakosSuper League Greece · Greece | 0–2 | Super League Greece · Greece |
| 2010-04-11 | UtrechtvDen HaagEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2010-04-11 | MallorcavValenciaLaLiga · Spain | 3–2 | LaLiga · Spain |
| 2010-04-11 | AjaxvVVV VenloEredivisie · Netherlands | 7–0 | Eredivisie · Netherlands |
| 2010-04-11 | LyonvLilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-04-11 | BlackburnvMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2010-04-11 | La CorunavSantanderLaLiga · Spain | 1–1 | LaLiga · Spain |
| 2010-04-11 | WolvesvStokePremier League · England | 0–0 | Premier League · England |
| 2010-04-11 | MaritimovBelenensesPrimeira Liga · Portugal | 3–3 | Primeira Liga · Portugal |
| 2010-04-11 | GroningenvWillem IIEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2010-04-11 | EspanolvAth MadridLaLiga · Spain | 3–0 | LaLiga · Spain |
| 2010-04-11 | DuisburgvGreuther Furth2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2010-04-11 | Man CityvBirminghamPremier League · England | 5–1 | Premier League · England |
| 2010-04-11 | NurnbergvWolfsburgBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2010-04-11 | PSV EindhovenvFeyenoordEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2010-04-11 | GenclerbirligivBursasporSüper Lig · Türkiye | 0–0 | Süper Lig · Türkiye |
| 2010-04-11 | SampdoriavGenoaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-04-11 | MarseillevNiceLigue 1 · France | 4–1 | Ligue 1 · France |
| 2010-04-11 | LevantevSalamancaLaLiga 2 · Spain | 2–0 | LaLiga 2 · Spain |
| 2010-04-11 | CordobavNumanciaLaLiga 2 · Spain | 2–1 | LaLiga 2 · Spain |
| 2010-04-11 | Ath BilbaovAlmeriaLaLiga · Spain | 4–1 | LaLiga · Spain |
| 2010-04-11 | XanthivAtromitosSuper League Greece · Greece | 2–1 | Super League Greece · Greece |
| 2010-04-11 | SienavBariSerie A · Italy | 3–2 | Serie A · Italy |
| 2010-04-11 | AberdeenvSt JohnstonePremiership · Scotland | 1–3 | Premiership · Scotland |
| 2010-04-11 | PalermovChievoSerie A · Italy | 3–1 | Serie A · Italy |
| 2010-04-11 | Frankfurt FSVvOberhausen2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2010-04-11 | LevadeiakosvAEKSuper League Greece · Greece | 0–0 | Super League Greece · Greece |
| 2010-04-11 | PAOKvKavalaSuper League Greece · Greece | 1–0 | Super League Greece · Greece |
| 2010-04-11 | BochumvHamburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-04-11 | GalatasarayvDiyarbakirsporSüper Lig · Türkiye | 4–1 | Süper Lig · Türkiye |
| 2010-04-11 | LiverpoolvFulhamPremier League · England | 0–0 | Premier League · England |
| 2010-04-11 | RomavAtalantaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-04-11 | JuventusvCagliariSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-04-11 | KarlsruhevHansa Rostock2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-04-11 | GuimaraesvOlhanensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-04-11 | Asteras TripolisvArisSuper League Greece · Greece | 2–1 | Super League Greece · Greece |
| 2010-04-11 | LivornovUdineseSerie A · Italy | 0–2 | Serie A · Italy |
| 2010-04-11 | ErgotelisvGianninaSuper League Greece · Greece | 3–1 | Super League Greece · Greece |
| 2010-04-10 | Rushden & DvEbbsfleetNational League · England | 2–0 | National League · England |