| 2021-08-29 | Werder BremenvHansa Rostock2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-08-29 | HeraclesvNijmegenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-08-29 | CittadellavCrotoneSerie B · Italy | 4–2 | Serie B · Italy |
| 2021-08-29 | VallecanovGranadaLa Liga · Spain | 4–0 | La Liga · Spain |
| 2021-08-29 | ValerengavStabaekEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-08-29 | AmorebietavAlmeriaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-08-29 | Ath MadridvVillarrealLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-08-29 | IndependientevColon Santa FELiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-08-29 | RiedvLASKBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-08-29 | SalernitanavRomaSerie A · Italy | 0–4 | Serie A · Italy |
| 2021-08-29 | MonzavCremoneseSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-08-29 | Tigres UANLvAtlasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-29 | BaselvYoung BoysSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-08-29 | WolvesvMan UnitedPremier League · England | 0–1 | Premier League · England |
| 2021-08-29 | DC UnitedvPhiladelphia UnionMLS · United States | 3–1 | MLS · United States |
| 2021-08-29 | BenficavTondelaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-08-29 | BurgosvEibarLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-08-29 | Central CordobavRosario CentralLiga Profesional · Argentina | 2–4 | Liga Profesional · Argentina |
| 2021-08-29 | SpalvPordenoneSerie B · Italy | 5–0 | Serie B · Italy |
| 2021-08-29 | AarhusvOdenseSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-08-29 | SilkeborgvRanders FCSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-08-29 | Union BerlinvM'gladbachBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-08-29 | LuzernvLausanneSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-08-29 | Nagoya GrampusvShimizu S-PulseJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-08-29 | Santa ClaravGil VicentePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-08-29 | GiresunsporvTrabzonsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-08-29 | Atletico GOvInternacionalSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-08-29 | WolfsburgvRB LeipzigBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-08-29 | KalmarvElfsborgAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2021-08-29 | UtrechtvFeyenoordEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-08-29 | St MirrenvSt JohnstonePremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-08-29 | Kashiwa ReysolvYokohama FCJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-08-29 | SassuolovSampdoriaSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-08-29 | GenkvAnderlechtPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-08-29 | SonderjyskevViborgSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-08-29 | GenoavNapoliSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-08-29 | LeccevComoSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-08-29 | Houston DynamovMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2021-08-29 | Sociedad BvFuenlabradaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-08-29 | AldosivivLanusLiga Profesional · Argentina | 2–3 | Liga Profesional · Argentina |
| 2021-08-29 | StrasbourgvBrestLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-08-29 | CFR ClujvFCSBSuperliga · Romania | 4–1 | Superliga · Romania |
| 2021-08-29 | BrondbyvMidtjyllandSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-08-29 | Club LeonvClub AmericaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-29 | DresdenvPaderborn2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-08-29 | HeerenveenvAZ AlkmaarEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-08-29 | GentvClub BruggePro League · Belgium | 6–1 | Pro League · Belgium |
| 2021-08-29 | ClermontvMetzLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-08-29 | Sepsi Sf. GheorghevFC BotosaniSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-08-29 | AntwerpvOud-Heverlee LeuvenPro League · Belgium | 2–2 | Pro League · Belgium |