| 2021-12-12 | Erzgebirge AuevDresden2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-12-12 | IntervCagliariSerie A · Italy | 4–0 | Serie A · Italy |
| 2021-12-12 | OlympiakosvArisSuper League · Greece | 1–0 | Super League · Greece |
| 2021-12-12 | Greuther FurthvUnion BerlinBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-12-12 | LeicestervNewcastlePremier League · England | 4–0 | Premier League · England |
| 2021-12-12 | RennesvNiceLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-12-12 | AjaxvAZ AlkmaarEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-12-12 | Yeni MalatyasporvAlanyasporSüper Lig · Turkey | 2–6 | Süper Lig · Turkey |
| 2021-12-12 | PAOKvLamiaSuper League · Greece | 2–1 | Super League · Greece |
| 2021-12-12 | St. GilloisevMechelenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-12-12 | CracoviavLecznaEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-12-12 | VillarrealvVallecanoLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-12-12 | TromsovVikingEliteserien · Norway | 0–2 | Eliteserien · Norway |
| 2021-12-12 | MoreirensevPortimonensePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-12-12 | Wuhan FCvCangzhouSuper League · China | 4–2 | Super League · China |
| 2021-12-12 | LillevLyonLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-12-12 | Ein FrankfurtvLeverkusenBundesliga · Germany | 5–2 | Bundesliga · Germany |
| 2021-12-12 | FamalicaovBenficaPrimeira Liga · Portugal | 1–4 | Primeira Liga · Portugal |
| 2021-12-12 | A. KlagenfurtvSturm GrazBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2021-12-12 | Dalian ProvHenan Songshan LongmenSuper League · China | 1–0 | Super League · China |
| 2021-12-12 | GentvGenkPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-12-12 | BelenensesvEstorilPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-12-12 | RosenborgvStromsgodsetEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-12-12 | TroyesvBordeauxLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-12-12 | KristiansundvValerengaEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-12-12 | LillestromvSandefjordEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2021-12-12 | MetzvLorientLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-12-12 | San LorenzovNewells Old BoysLiga Profesional · Argentina | 3–2 | Liga Profesional · Argentina |
| 2021-12-11 | Le HavrevAjaccioLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-12-11 | SeraingvAnderlechtPro League · Belgium | 0–5 | Pro League · Belgium |
| 2021-12-11 | VeneziavJuventusSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-12-11 | PisavLecceSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-12-11 | RiedvAltachBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-12-11 |  Moroccov AlgeriaArab Cup | 2–2 p | Arab Cup |
| 2021-12-11 | Kelty HeartsvAlbion RvsLeague Two · Scotland | 6–1 | League Two · Scotland |
| 2021-12-11 | St TruidenvCercle BruggePro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-12-11 | Annan AthleticvElginLeague Two · Scotland | 4–1 | League Two · Scotland |
| 2021-12-11 | BradfordvSuttonLeague Two · England | 2–2 | League Two · England |
| 2021-12-11 | Gaz Metan MediasvFCSBSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-12-11 | Argentinos JrsvSarmiento JuninLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-12-11 | LutonvFulhamChampionship · England | 1–1 | Championship · England |
| 2021-12-11 | CSKA MoscowvArsenal TulaPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-12-11 | Newport CountyvPort ValeLeague Two · England | 2–1 | League Two · England |
| 2021-12-11 | Asteras TripolisvAEKSuper League · Greece | 0–0 | Super League · Greece |
| 2021-12-11 | StranraervCowdenbeathLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-12-11 | ChelseavLeedsPremier League · England | 3–2 | Premier League · England |
| 2021-12-11 | DoncastervShrewsburyLeague One · England | 1–0 | League One · England |
| 2021-12-11 | ValenciavElcheLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-12-11 | EspanolvLevanteLa Liga · Spain | 4–3 | La Liga · Spain |
| 2021-12-11 | AmiensvGrenobleLigue 2 · France | 4–1 | Ligue 2 · France |