| 2010-12-04 | AscolivPadovaSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-12-04 | St TruidenvKortrijkPro League · Belgium | 1–0 | Pro League · Belgium |
| 2010-12-04 | Real MadridvValenciaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-12-04 |  Thailandv MalaysiaAFF Championship | 0–0 | AFF Championship |
| 2010-12-04 | CordobavRecreativoLa Liga 2 · Spain | 3–3 | La Liga 2 · Spain |
| 2010-12-04 | CoventryvMiddlesbroughChampionship · England | 1–0 | Championship · England |
| 2010-12-04 | LillevLorientLigue 1 · France | 6–3 | Ligue 1 · France |
| 2010-12-04 | ManisasporvGaziantepsporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2010-12-04 | LevantevAth MadridLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-12-04 | M'gladbachvHannoverBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-12-04 | NorthamptonvStockportLeague Two · England | 2–0 | League Two · England |
| 2010-12-04 | ChelseavEvertonPremier League · England | 1–1 | Premier League · England |
| 2010-12-04 | CittadellavTriestinaSerie B · Italy | 4–1 | Serie B · Italy |
| 2010-12-04 | LensvAuxerreLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-12-04 | KasimpasavGalatasaraySüper Lig · Turkey | 0–3 | Süper Lig · Turkey |
| 2010-12-04 | MontpelliervLyonLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-12-04 | SassuolovPiacenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-12-04 | GimnasticvVillarreal BLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-12-04 | GuimaraesvPacos FerreiraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-12-04 | Man CityvBoltonPremier League · England | 1–0 | Premier League · England |
| 2010-12-04 | OxfordvBarnetLeague Two · England | 2–1 | League Two · England |
| 2010-12-04 | IraklisvErgotelisSuper League · Greece | 1–1 | Super League · Greece |
| 2010-12-04 | Rennesv MonacoLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-12-04 | LivornovPescaraSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-12-04 | NovaravCrotoneSerie B · Italy | 3–0 | Serie B · Italy |
| 2010-12-04 | WatfordvLeicesterChampionship · England | 3–2 | Championship · England |
| 2010-12-04 | PanathinaikosvPanserraikosSuper League · Greece | 2–0 | Super League · Greece |
| 2010-12-04 |  Indonesiav LaosAFF Championship | 6–0 | AFF Championship |
| 2010-12-04 | PanioniosvKerkyraSuper League · Greece | 0–1 | Super League · Greece |
| 2010-12-04 | MilanvBresciaSerie A · Italy | 3–0 | Serie A · Italy |
| 2010-12-04 | WiganvStokePremier League · England | 2–2 | Premier League · England |
| 2010-12-04 | BielefeldvGreuther Furth2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |
| 2010-12-04 | LeiriavSp BragaPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-12-04 | AlbinoleffevEmpoliSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-12-04 | StuttgartvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-12-04 | AjaxvNijmegenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2010-12-04 | ArlesvNancyLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-12-04 | HuescavAlcorconLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2010-12-04 | NumanciavBetisLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-12-04 | IpswichvSwanseaChampionship · England | 1–3 | Championship · England |
| 2010-12-04 | BlackburnvWolvesPremier League · England | 3–0 | Premier League · England |
| 2010-12-04 | AugsburgvCottbus2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2010-12-04 | LeedsvCrystal PalaceChampionship · England | 2–1 | Championship · England |
| 2010-12-04 | Schalke 04vBayern MunichBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-12-04 | GrossetovModenaSerie B · Italy | 3–1 | Serie B · Italy |
| 2010-12-04 | EupenvGentPro League · Belgium | 0–3 | Pro League · Belgium |
| 2010-12-04 | Ein FrankfurtvMainzBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-12-04 | SwindonvSheffield WedsLeague One · England | 2–1 | League One · England |
| 2010-12-04 | ArsenalvFulhamPremier League · England | 2–1 | Premier League · England |
| 2010-12-04 | TwentevGraafschapEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |