| 2010-04-11 | GalatasarayvDiyarbakirsporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2010-04-11 | LiverpoolvFulhamPremier League · England | 0–0 | Premier League · England |
| 2010-04-11 | RomavAtalantaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-04-11 | JuventusvCagliariSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-04-11 | KarlsruhevHansa Rostock2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-04-11 | GuimaraesvOlhanensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-04-11 | Asteras TripolisvArisSuper League · Greece | 2–1 | Super League · Greece |
| 2010-04-11 | LivornovUdineseSerie A · Italy | 0–2 | Serie A · Italy |
| 2010-04-11 | ErgotelisvGianninaSuper League · Greece | 3–1 | Super League · Greece |
| 2010-04-10 | Rushden & DvEbbsfleetNational League · England | 2–0 | National League · England |
| 2010-04-10 | Le MansvMontpellierLigue 1 · France | 2–2 | Ligue 1 · France |
| 2010-04-10 | VillarrealvSp GijonLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-04-10 | FalkirkvSt MirrenPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2010-04-10 | ColchestervSwindonLeague One · England | 3–0 | League One · England |
| 2010-04-10 | CrewevShrewsburyLeague Two · England | 0–3 | League Two · England |
| 2010-04-10 | SouthamptonvCharltonLeague One · England | 1–0 | League One · England |
| 2010-04-10 | TriestinavBresciaSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-04-10 | LeccevTorinoSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-04-10 | RegginavEmpoliSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-04-10 | HullvBurnleyPremier League · England | 1–4 | Premier League · England |
| 2010-04-10 | HamiltonvHibernianPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2010-04-10 | HerthavStuttgartBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2010-04-10 | BesiktasvTrabzonsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2010-04-10 | ChesterfieldvDag and RedLeague Two · England | 2–2 | League Two · England |
| 2010-04-10 | Crystal PalacevQPRChampionship · England | 0–2 | Championship · England |
| 2010-04-10 | StevenagevForest GreenNational League · England | 2–0 | National League · England |
| 2010-04-10 | TenerifevValladolidLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-04-10 | SochauxvSt EtienneLigue 1 · France | 0–2 | Ligue 1 · France |
| 2010-04-10 | HerefordvGrimsbyLeague Two · England | 0–1 | League Two · England |
| 2010-04-10 | StenhousemuirvClydeLeague One · Scotland | 0–3 | League One · Scotland |
| 2010-04-10 | LivingstonvForfarLeague Two · Scotland | 2–3 | League Two · Scotland |
| 2010-04-10 | OldhamvBristol RvsLeague One · England | 2–1 | League One · England |
| 2010-04-10 | SalisburyvCambridgeNational League · England | 2–1 | National League · England |
| 2010-04-10 | AlbinoleffevCesenaSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-04-10 | LincolnvBournemouthLeague Two · England | 2–1 | League Two · England |
| 2010-04-10 | DumbartonvEast FifeLeague One · Scotland | 0–1 | League One · Scotland |
| 2010-04-10 | AlbacetevGimnasticLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-04-10 | NewcastlevBlackpoolChampionship · England | 4–1 | Championship · England |
| 2010-04-10 | GraysvWrexhamNational League · England | 0–2 | National League · England |
| 2010-04-10 | BarnetvMacclesfieldLeague Two · England | 1–2 | League Two · England |
| 2010-04-10 | ToulousevGrenobleLigue 1 · France | 4–0 | Ligue 1 · France |
| 2010-04-10 | MantovavPiacenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-04-10 | Rio AvevPortoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2010-04-10 | StranraervQueens ParkLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2010-04-10 | Real UnionvElcheLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2010-04-10 | AlloavBrechinLeague One · Scotland | 2–3 | League One · Scotland |
| 2010-04-10 | LeiriavSp BragaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2010-04-10 | PeterheadvCowdenbeathLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-04-10 | AltrinchamvOxfordNational League · England | 0–1 | National League · England |
| 2010-04-10 | Bristol CityvSwanseaChampionship · England | 1–0 | Championship · England |