| 2010-04-17 | Milton Keynes DonsvWycombeLeague One · England | 2–3 | League One · England |
| 2010-04-17 | Forest GreenvHistonNational League · England | 2–0 | National League · England |
| 2010-04-17 | ElginvEast StirlingLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2010-04-17 | AldershotvCreweLeague Two · England | 1–1 | League Two · England |
| 2010-04-16 | BursasporvGaziantepsporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2010-04-16 | ClermontvMetzLigue 2 · France | 2–0 | Ligue 2 · France |
| 2010-04-16 | ChateaurouxvNantesLigue 2 · France | 2–2 | Ligue 2 · France |
| 2010-04-16 | Greuther FurthvPaderborn2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2010-04-16 | StrasbourgvDijonLigue 2 · France | 3–1 | Ligue 2 · France |
| 2010-04-16 | GironavLevanteLa Liga 2 · Spain | 0–4 | La Liga 2 · Spain |
| 2010-04-16 | AngersvToursLigue 2 · France | 0–1 | Ligue 2 · France |
| 2010-04-16 | KoblenzvKarlsruhe2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2010-04-16 | OlhanensevMaritimoPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2010-04-16 | ArlesvGuingampLigue 2 · France | 1–1 | Ligue 2 · France |
| 2010-04-16 | BrestvBastiaLigue 2 · France | 4–0 | Ligue 2 · France |
| 2010-04-16 | VannesvIstresLigue 2 · France | 2–0 | Ligue 2 · France |
| 2010-04-16 | IntervJuventusSerie A · Italy | 2–0 | Serie A · Italy |
| 2010-04-16 | AugsburgvDuisburg2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2010-04-16 | HuddersfieldvMillwallLeague One · England | 1–0 | League One · England |
| 2010-04-16 | SedanvLavalLigue 2 · France | 0–0 | Ligue 2 · France |
| 2010-04-16 | FC KolnvBochumBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-04-15 | AlmeriavReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2010-04-15 | Hayes & YeadingvKidderminsterNational League · England | 2–2 | National League · England |
| 2010-04-15 | ValenciavAth BilbaoLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-04-15 | BarrowvCrawley TownNational League · England | 4–1 | National League · England |
| 2010-04-14 | HeerenveenvPSV EindhovenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2010-04-14 | Dundee UnitedvRangersPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2010-04-14 | BarcelonavLa CorunaLa Liga · Spain | 3–0 | La Liga · Spain |
| 2010-04-14 | Ath MadridvXerezLa Liga · Spain | 1–2 | La Liga · Spain |
| 2010-04-14 | SochauxvMarseilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-04-14 | Willem IIvAjaxEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2010-04-14 | ZaragozavMallorcaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2010-04-14 | Den HaagvNijmegenEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2010-04-14 | OsasunavMalagaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2010-04-14 | TottenhamvArsenalPremier League · England | 2–1 | Premier League · England |
| 2010-04-14 | Aston VillavEvertonPremier League · England | 2–2 | Premier League · England |
| 2010-04-14 | Airdrie UtdvRaith RvsChampionship · Scotland | 3–0 | Championship · Scotland |
| 2010-04-14 | StranraervAlbion RvsLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2010-04-14 | FeyenoordvSpartaEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2010-04-14 | UtrechtvGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2010-04-14 | AltrinchamvStevenageNational League · England | 0–1 | National League · England |
| 2010-04-14 | StirlingvBrechinLeague One · Scotland | 6–2 | League One · Scotland |
| 2010-04-14 | Roda JCvVVV VenloEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2010-04-14 | WiganvPortsmouthPremier League · England | 0–0 | Premier League · England |
| 2010-04-14 | SantandervEspanolLa Liga · Spain | 3–1 | La Liga · Spain |
| 2010-04-14 | Le MansvBordeauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-04-13 | MortonvRoss CountyChampionship · Scotland | 1–1 | Championship · Scotland |
| 2010-04-13 | ReadingvNewcastleChampionship · England | 1–2 | Championship · England |
| 2010-04-13 | CrotonevModenaSerie B · Italy | 4–2 | Serie B · Italy |
| 2010-04-13 | Leyton OrientvNorwichLeague One · England | 2–1 | League One · England |