| 2010-04-17 | StuttgartvLeverkusenBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-04-17 | HamiltonvKilmarnockPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2010-04-17 | MortonvDundeeChampionship · Scotland | 2–2 | Championship · Scotland |
| 2010-04-17 | AccringtonvHerefordLeague Two · England | 1–2 | League Two · England |
| 2010-04-17 | LeccevBresciaSerie B · Italy | 2–2 | Serie B · Italy |
| 2010-04-17 | ArbroathvCowdenbeathLeague One · Scotland | 1–1 | League One · Scotland |
| 2010-04-17 | Annan AthleticvStranraerLeague Two · Scotland | 3–2 | League Two · Scotland |
| 2010-04-17 | MacclesfieldvChesterfieldLeague Two · England | 2–0 | League Two · England |
| 2010-04-17 | CittadellavTriestinaSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-04-17 | HartlepoolvColchesterLeague One · England | 3–1 | League One · England |
| 2010-04-17 | VillarrealvAth MadridLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-04-17 | WrexhamvRushden & DNational League · England | 0–1 | National League · England |
| 2010-04-17 | ManisasporvGalatasaraySüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2010-04-17 | Kettering TownvEastbourne BoroughNational League · England | 4–0 | National League · England |
| 2010-04-17 | BirminghamvHullPremier League · England | 0–0 | Premier League · England |
| 2010-04-17 | BournemouthvDarlingtonLeague Two · England | 2–0 | League Two · England |
| 2010-04-17 | HamburgvMainzBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2010-04-17 | BlackburnvEvertonPremier League · England | 2–3 | Premier League · England |
| 2010-04-17 | ReadingvPeterboroChampionship · England | 6–0 | Championship · England |
| 2010-04-17 | StokevBoltonPremier League · England | 1–2 | Premier League · England |
| 2010-04-17 | AlloavDumbartonLeague One · Scotland | 1–2 | League One · Scotland |
| 2010-04-17 | St JohnstonevSt MirrenPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2010-04-17 | GillinghamvLeedsLeague One · England | 3–2 | League One · England |
| 2010-04-17 | Union BerlinvSt Pauli2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-04-17 | AnconavAscoliSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-04-17 | FreiburgvNurnbergBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-04-17 | CarlislevOldhamLeague One · England | 1–2 | League One · England |
| 2010-04-17 | EmpolivPadovaSerie B · Italy | 4–0 | Serie B · Italy |
| 2010-04-17 | QPRvCardiffChampionship · England | 0–1 | Championship · England |
| 2010-04-17 | Notts CountyvMorecambeLeague Two · England | 4–1 | League Two · England |
| 2010-04-17 | DerbyvCrystal PalaceChampionship · England | 1–1 | Championship · England |
| 2010-04-17 | CelticvHibernianPremiership · Scotland | 3–2 | Premiership · Scotland |
| 2010-04-17 | GimnasticvCartagenaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2010-04-17 | CambridgevHayes & YeadingNational League · England | 4–1 | National League · England |
| 2010-04-17 | LivingstonvBerwickLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2010-04-17 | SwanseavBarnsleyChampionship · England | 3–1 | Championship · England |
| 2010-04-17 | LeicestervWatfordChampionship · England | 4–1 | Championship · England |
| 2010-04-17 | ChievovLivornoSerie A · Italy | 2–0 | Serie A · Italy |
| 2010-04-17 | SunderlandvBurnleyPremier League · England | 2–1 | Premier League · England |
| 2010-04-17 | BoulognevMarseilleLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-04-17 | SevillavSp GijonLa Liga · Spain | 3–0 | La Liga · Spain |
| 2010-04-17 | CharltonvNorwichLeague One · England | 0–1 | League One · England |
| 2010-04-17 | SalernitanavGrossetoSerie B · Italy | 3–4 | Serie B · Italy |
| 2010-04-17 | RotherhamvCheltenhamLeague Two · England | 0–0 | League Two · England |
| 2010-04-17 | ClydevPeterheadLeague One · Scotland | 3–1 | League One · Scotland |
| 2010-04-17 | Albion RvsvQueens ParkLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2010-04-17 | RochdalevNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2010-04-17 | YeovilvSouthamptonLeague One · England | 0–1 | League One · England |
| 2010-04-17 | FulhamvWolvesPremier League · England | 0–0 | Premier League · England |
| 2010-04-17 | YorkvGraysNational League · England | 1–1 | National League · England |