| 2021-09-11 | MotherwellvAberdeenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-09-11 | AmorebietavBurgosLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-09-11 | Sp LisbonvPortoPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-09-11 | BragantinovChapecoense-SCSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-09-11 | HIFKvAC OuluVeikkausliiga · Finland | 3–1 | Veikkausliiga · Finland |
| 2021-09-11 | HalifaxvSouthendNational League · England | 3–1 | National League · England |
| 2021-09-11 | Union BerlinvAugsburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-09-11 | Cove RangersvMontroseLeague One · Scotland | 1–1 | League One · Scotland |
| 2021-09-11 | AldershotvSolihullNational League · England | 1–2 | National League · England |
| 2021-09-11 | WalsallvMansfieldLeague Two · England | 3–1 | League Two · England |
| 2021-09-11 | BlackburnvLutonChampionship · England | 2–2 | Championship · England |
| 2021-09-11 | MirandesvAlcorconLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2021-09-11 | IngolstadtvWerder Bremen2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-09-11 | ScunthorpevExeterLeague Two · England | 0–4 | League Two · England |
| 2021-09-11 | Lokomotiv MoscowvKrylya SovetovPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-09-11 | DumbartonvEast FifeLeague One · Scotland | 5–0 | League One · Scotland |
| 2021-09-11 | ValenciennesvQuevilly RouenLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-09-11 | Greuther FurthvWolfsburgBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-09-11 | AjacciovSochauxLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-09-11 | LillestromvBrannEliteserien · Norway | 2–3 | Eliteserien · Norway |
| 2021-09-11 | KuPSvSJKVeikkausliiga · Finland | 3–0 | Veikkausliiga · Finland |
| 2021-09-11 | CelticvRoss CountyPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2021-09-11 | Dover AthleticvChesterfieldNational League · England | 0–0 | National League · England |
| 2021-09-11 | Ath BilbaovMallorcaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-09-11 | WealdstonevAltrinchamNational League · England | 1–0 | National League · England |
| 2021-09-11 | WiganvDoncasterLeague One · England | 2–1 | League One · England |
| 2021-09-11 | Malmo FFvNorrkopingAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-09-11 | ReadingvQPRChampionship · England | 3–3 | Championship · England |
| 2021-09-11 | Warta PoznanvTermalica B-B.Ekstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-09-11 | AlloavFalkirkLeague One · Scotland | 2–0 | League One · Scotland |
| 2021-09-11 | HonkavKTPVeikkausliiga · Finland | 3–1 | Veikkausliiga · Finland |
| 2021-09-11 | Sagan TosuvShimizu S-PulseJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-09-11 | HoffenheimvMainzBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-09-11 | CambridgevLincolnLeague One · England | 1–5 | League One · England |
| 2021-09-11 | BesiktasvYeni MalatyasporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-09-11 | America MGvAthletico-PRSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-09-11 | Man UnitedvNewcastlePremier League · England | 4–1 | Premier League · England |
| 2021-09-11 | StranraervEdinburgh CityLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-09-11 | LeicestervMan CityPremier League · England | 0–1 | Premier League · England |
| 2021-09-11 | LeverkusenvDortmundBundesliga · Germany | 3–4 | Bundesliga · Germany |
| 2021-09-11 | KonyasporvAltaySüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-09-11 | Pacos FerreiravSp BragaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-09-11 | SwanseavHullChampionship · England | 0–0 | Championship · England |
| 2021-09-11 | AtlasvMonterreyLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-09-10 | Club BruggevOostendePro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-09-10 | Sligo RoversvSt. PatricksPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2021-09-10 | LorientvLilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-09-10 | MiovenivChindia TargovisteSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-09-10 | HarrogatevNewport CountyLeague Two · England | 2–2 | League Two · England |
| 2021-09-10 | BeneventovLecceSerie B · Italy | 0–0 | Serie B · Italy |