| 2010-04-17 | West BromvMiddlesbroughChampionship · England | 2–0 | Championship · England |
| 2010-04-17 | AuxerrevLorientLigue 1 · France | 4–1 | Ligue 1 · France |
| 2010-04-17 | Bayern MunichvHannoverBundesliga · Germany | 7–0 | Bundesliga · Germany |
| 2010-04-17 | EspanolvBarcelonaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-04-17 | ModenavAlbinoleffeSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-04-17 | GrimsbyvTorquayLeague Two · England | 0–3 | League Two · England |
| 2010-04-17 | RennesvNancyLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-04-17 | ForfarvMontroseLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2010-04-17 | HuescavRecreativoLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-04-17 | BradfordvBarnetLeague Two · England | 2–1 | League Two · England |
| 2010-04-17 | SociedadvAlbaceteLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-04-17 | FrosinonevVicenzaSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-04-17 | KidderminstervStevenageNational League · England | 0–2 | National League · England |
| 2010-04-17 | SouthendvBrightonLeague One · England | 0–1 | League One · England |
| 2010-04-17 | Leyton OrientvStockportLeague One · England | 2–0 | League One · England |
| 2010-04-17 | Pacos FerreiravNavalPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2010-04-17 | ShrewsburyvLincolnLeague Two · England | 1–0 | League Two · England |
| 2010-04-17 | EbbsfleetvGatesheadNational League · England | 2–0 | National League · England |
| 2010-04-17 | OxfordvMansfieldNational League · England | 2–0 | National League · England |
| 2010-04-17 | CoventryvPrestonChampionship · England | 1–1 | Championship · England |
| 2010-04-17 | NicevLensLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-04-17 | Bristol RvsvBrentfordLeague One · England | 0–0 | League One · England |
| 2010-04-17 | BarrowvSalisburyNational League · England | 0–1 | National League · England |
| 2010-04-17 | TranmerevExeterLeague One · England | 3–1 | League One · England |
| 2010-04-17 | BrechinvEast FifeLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-04-17 | TorinovCesenaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-04-17 | PartickvAyrChampionship · Scotland | 0–1 | Championship · Scotland |
| 2010-04-17 | SwindonvWalsallLeague One · England | 1–1 | League One · England |
| 2010-04-17 | BlackpoolvNott'm ForestChampionship · England | 3–1 | Championship · England |
| 2010-04-17 | BuyuksehyrvGenclerbirligiSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2010-04-17 | GrenoblevSochauxLigue 1 · France | 2–2 | Ligue 1 · France |
| 2010-04-17 | Hansa RostockvFrankfurt FSV2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2010-04-17 | LutonvAltrinchamNational League · England | 0–0 | National League · England |
| 2010-04-17 | IpswichvDoncasterChampionship · England | 1–1 | Championship · England |
| 2010-04-17 | Dag and RedvBurtonLeague Two · England | 2–1 | League Two · England |
| 2010-04-17 | WolfsburgvWerder BremenBundesliga · Germany | 2–4 | Bundesliga · Germany |
| 2010-04-17 | Inverness CvDunfermlineChampionship · Scotland | 2–0 | Championship · Scotland |
| 2010-04-17 | StenhousemuirvStirlingLeague One · Scotland | 1–3 | League One · Scotland |
| 2010-04-17 | AberdeenvFalkirkPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2010-04-17 | Schalke 04vM'gladbachBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2010-04-17 | BordeauxvLyonLigue 1 · France | 2–2 | Ligue 1 · France |
| 2010-04-17 | Airdrie UtdvRoss CountyChampionship · Scotland | 1–1 | Championship · Scotland |
| 2010-04-17 | BuryvPort ValeLeague Two · England | 1–1 | League Two · England |
| 2010-04-17 | Sp BragavLeixoesPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-04-17 | ValenciennesvLe MansLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-04-17 | ScunthorpevBristol CityChampionship · England | 3–0 | Championship · England |
| 2010-04-17 | TottenhamvChelseaPremier League · England | 2–1 | Premier League · England |
| 2010-04-17 | Man CityvMan UnitedPremier League · England | 0–1 | Premier League · England |
| 2010-04-17 | Crawley TownvTamworthNational League · England | 2–0 | National League · England |
| 2010-04-17 | MantovavGallipoliSerie B · Italy | 1–0 | Serie B · Italy |