| 2021-09-11 | Wolfsberger ACvHartbergBundesliga · Austria | 1–3 | Bundesliga · Austria |
| 2021-09-11 | Milton Keynes DonsvPortsmouthLeague One · England | 1–0 | League One · England |
| 2021-09-11 | Crystal PalacevTottenhamPremier League · England | 3–0 | Premier League · England |
| 2021-09-11 | Leyton OrientvOldhamLeague Two · England | 4–0 | League Two · England |
| 2021-09-11 | ComovAscoliSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-09-11 | HartlepoolvBristol RvsLeague Two · England | 1–0 | League Two · England |
| 2021-09-11 | ArbroathvHamiltonChampionship · Scotland | 4–0 | Championship · Scotland |
| 2021-09-11 | PeterheadvClydeLeague One · Scotland | 3–2 | League One · Scotland |
| 2021-09-11 | Raith RvsvQueen of SthChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-09-11 | Inverness CvPartickChampionship · Scotland | 3–1 | Championship · Scotland |
| 2021-09-11 | JagielloniavStal MielecEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-09-11 | AtalantavFiorentinaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-09-11 | Yokohama FCvUrawa RedsJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-09-11 | SpalvMonzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-09-11 | CoventryvMiddlesbroughChampionship · England | 2–0 | Championship · England |
| 2021-09-11 | HamburgvSandhausen2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-09-11 | Oita TrinitavShonan BellmareJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-09-11 | WaregemvCercle BruggePro League · Belgium | 2–4 | Pro League · Belgium |
| 2021-09-11 | WeymouthvNotts CountyNational League · England | 1–1 | National League · England |
| 2021-09-11 | SouthamptonvWest HamPremier League · England | 0–0 | Premier League · England |
| 2021-09-11 | EmpolivVeneziaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-09-11 | Forest GreenvNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2021-09-11 | WrexhamvWokingNational League · England | 1–0 | National League · England |
| 2021-09-11 | FreiburgvFC KolnBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-09-11 | CaenvPau FCLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-09-11 | WatfordvWolvesPremier League · England | 0–2 | Premier League · England |
| 2021-09-11 | RB LeipzigvBayern MunichBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2021-09-11 | CambuurvGo Ahead EaglesEredivisie · Netherlands | 5–2 | Eredivisie · Netherlands |
| 2021-09-11 | Sociedad BvEibarLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2021-09-11 | SuttonvStevenageLeague Two · England | 2–1 | League Two · England |
| 2021-09-11 | CharltonvCheltenhamLeague One · England | 1–2 | League One · England |
| 2021-09-11 | ShrewsburyvCreweLeague One · England | 1–1 | League One · England |
| 2021-09-11 | TernanavPisaSerie B · Italy | 1–4 | Serie B · Italy |
| 2021-09-11 | SunderlandvAccringtonLeague One · England | 2–1 | League One · England |
| 2021-09-11 | MorecambevAFC WimbledonLeague One · England | 3–4 | League One · England |
| 2021-09-11 | ArsenalvNorwichPremier League · England | 1–0 | Premier League · England |
| 2021-09-11 | GrenoblevNimesLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-09-11 | FC ArgesvU Craiova 1948Superliga · Romania | 1–0 | Superliga · Romania |
| 2021-09-11 | Young BoysvZurichSuper League · Switzerland | 4–0 | Super League · Switzerland |
| 2021-09-11 | DijonvBastiaLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-09-11 | ChelseavAston VillaPremier League · England | 3–0 | Premier League · England |
| 2021-09-11 | Seattle SoundersvMinnesota UnitedMLS · United States | 1–0 | MLS · United States |
| 2021-09-11 | StokevHuddersfieldChampionship · England | 2–1 | Championship · England |
| 2021-09-11 | Colorado RapidsvLos Angeles GalaxyMLS · United States | 1–1 | MLS · United States |
| 2021-09-11 | AmiensvRodezLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-09-11 | CrotonevRegginaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-09-11 | PueblavAtl. San LuisLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-09-11 | BromleyvBoreham WoodNational League · England | 2–3 | National League · England |
| 2021-09-11 | TwentevUtrechtEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-09-11 | CracoviavGornik Z.Ekstraklasa · Poland | 2–2 | Ekstraklasa · Poland |