| 2010-04-18 | NumanciavHerculesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-04-18 | FenerbahcevBesiktasSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2010-04-18 | La CorunavAlmeriaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-04-18 | PSV EindhovenvGroningenEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2010-04-18 | AjaxvHeraclesEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2010-04-18 | PAOKvErgotelisSuper League · Greece | 4–1 | Super League · Greece |
| 2010-04-18 | AtromitosvPanthrakikosSuper League · Greece | 3–1 | Super League · Greece |
| 2010-04-18 | ElchevCastellonLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-04-18 | MurciavVallecanoLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2010-04-18 | XerezvSantanderLa Liga · Spain | 2–2 | La Liga · Spain |
| 2010-04-18 | AtalantavFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-04-18 | RangersvHeartsPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2010-04-18 | ParmavGenoaSerie A · Italy | 2–3 | Serie A · Italy |
| 2010-04-18 | Real MadridvValenciaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-04-18 | AhlenvAachen2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2010-04-18 | GianninavPanathinaikosSuper League · Greece | 0–1 | Super League · Greece |
| 2010-04-18 | KavalavPanioniosSuper League · Greece | 1–1 | Super League · Greece |
| 2010-04-18 | Willem IIvAZ AlkmaarEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2010-04-18 | CagliarivPalermoSerie A · Italy | 2–2 | Serie A · Italy |
| 2010-04-18 | DiyarbakirsporvKayserisporSüper Lig · Turkey | 0–3 | Süper Lig · Turkey |
| 2010-04-18 | MontpelliervToulouseLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-04-18 | IraklisvXanthiSuper League · Greece | 2–4 | Super League · Greece |
| 2010-04-18 | MalagavValladolidLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-04-18 | SampdoriavMilanSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-04-18 | AcademicavBenficaPrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2010-04-18 | Ath BilbaovZaragozaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-04-18 | St EtiennevParis SGLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-04-18 | UdinesevBolognaSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-04-18 | Den HaagvWaalwijkEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2010-04-18 | LarisavLevadeiakosSuper League · Greece | 1–2 | Super League · Greece |
| 2010-04-18 | BelenensesvRio AvePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2010-04-18 | TwentevFeyenoordEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-04-18 | VVV VenlovNijmegenEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-04-18 | VitessevRoda JCEredivisie · Netherlands | 2–5 | Eredivisie · Netherlands |
| 2010-04-18 | OlympiakosvArisSuper League · Greece | 2–1 | Super League · Greece |
| 2010-04-18 | Ein FrankfurtvHerthaBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2010-04-18 | WiganvArsenalPremier League · England | 3–2 | Premier League · England |
| 2010-04-18 | PortsmouthvAston VillaPremier League · England | 1–2 | Premier League · England |
| 2010-04-18 | Las PalmasvReal UnionLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2010-04-18 | CadizvVillarreal BLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-04-18 | AEKvAsteras TripolisSuper League · Greece | 2–0 | Super League · Greece |
| 2010-04-18 | OberhausenvCottbus2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2010-04-18 | MotherwellvDundee UnitedPremiership · Scotland | 2–3 | Premiership · Scotland |
| 2010-04-18 | SpartavUtrechtEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2010-04-18 | CeltavBetisLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-04-18 | HeerenveenvNAC BredaEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2010-04-18 | PortovGuimaraesPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2010-04-18 | TenerifevGetafeLa Liga · Spain | 3–2 | La Liga · Spain |
| 2010-04-18 | SalamancavCordobaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2010-04-17 | Queen of SthvRaith RvsChampionship · Scotland | 3–0 | Championship · Scotland |