| 2021-09-11 | OxfordvWycombeLeague One · England | 0–0 | League One · England |
| 2021-09-11 | Cerezo OsakavHokkaido Consadole SapporoJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-09-11 | BlackpoolvFulhamChampionship · England | 1–0 | Championship · England |
| 2021-09-11 | Sanfrecce HiroshimavYokohama F. MarinosJ1 League · Japan | 1–3 | J1 League · Japan |
| 2021-09-11 | Queens ParkvAirdrie UtdLeague One · Scotland | 0–0 | League One · Scotland |
| 2021-09-11 | LevantevVallecanoLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-09-11 | BarnetvEastleighNational League · England | 1–1 | National League · England |
| 2021-09-11 | TorquayvGrimsbyNational League · England | 1–3 | National League · England |
| 2021-09-11 | StabaekvVikingEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-09-11 | ZenitvAkhmat GroznyPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-09-11 | StockportvYeovilNational League · England | 0–3 | National League · England |
| 2021-09-11 | Kashima AntlersvAvispa FukuokaJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-09-11 | KayserisporvKasimpasaSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-09-11 | LongfordvDundalkPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-09-11 | FC BotosanivCFR ClujSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-09-11 | Albion RvsvCowdenbeathLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2021-09-11 | West BromvMillwallChampionship · England | 1–1 | Championship · England |
| 2021-09-11 | Paris SGvClermontLigue 1 · France | 4–0 | Ligue 1 · France |
| 2021-09-11 | AuxerrevNiortLigue 2 · France | 4–0 | Ligue 2 · France |
| 2021-09-11 | Kings LynnvDag and RedNational League · England | 1–2 | National League · England |
| 2021-09-11 | KaragumrukvAd. DemirsporSüper Lig · Turkey | 4–0 | Süper Lig · Turkey |
| 2021-09-11 | HakavMariehamnVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |
| 2021-09-11 | BrentfordvBrightonPremier League · England | 0–1 | Premier League · England |
| 2021-09-11 | TirolvSalzburgBundesliga · Austria | 1–3 | Bundesliga · Austria |
| 2021-09-11 | Slask WroclawvLegiaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-09-11 | EupenvAntwerpPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-09-11 | RotherhamvFleetwood TownLeague One · England | 2–4 | League One · England |
| 2021-09-11 | JuventudevCuiabaSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-09-11 | Vancouver WhitecapsvPortland TimbersMLS · United States | 0–1 | MLS · United States |
| 2021-09-11 | RochdalevTranmereLeague Two · England | 1–0 | League Two · England |
| 2021-09-11 | SK RapidvAdmiraBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2021-09-11 | Crawley TownvCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-09-11 | ZwollevAjaxEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-09-11 | Las PalmasvIbizaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-09-11 | St JohnstonevRangersPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-09-11 | DundeevLivingstonPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-09-11 | Atlanta UtdvOrlando CityMLS · United States | 3–0 | MLS · United States |
| 2021-09-11 | AyrvDunfermlineChampionship · Scotland | 3–1 | Championship · Scotland |
| 2021-09-11 | Paris FCvGuingampLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-09-11 | Sheffield UnitedvPeterboroChampionship · England | 6–2 | Championship · England |
| 2021-09-11 | SiriusvOstersundsAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-09-11 | PanathinaikosvApollonSuper League · Greece | 4–0 | Super League · Greece |
| 2021-09-11 | SalfordvBradfordLeague Two · England | 1–0 | League Two · England |
| 2021-09-11 | HannovervSt Pauli2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-09-11 | JuarezvCruz AzulLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-09-11 | BurtonvGillinghamLeague One · England | 1–1 | League One · England |
| 2021-09-11 | Inter TurkuvHJKVeikkausliiga · Finland | 1–3 | Veikkausliiga · Finland |
| 2021-09-11 | SwindonvPort ValeLeague Two · England | 1–2 | League Two · England |
| 2021-09-11 | Annan AthleticvStenhousemuirLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2021-09-11 | BournemouthvBarnsleyChampionship · England | 3–0 | Championship · England |