| 2021-09-12 | Houston DynamovAustin FCMLS · United States | 3–0 | MLS · United States |
| 2021-09-12 | LausannevSionSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-09-12 | StromsgodsetvKristiansundEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-09-12 | MoldevMjondalenEliteserien · Norway | 4–0 | Eliteserien · Norway |
| 2021-09-12 | GenkvSt. GilloisePro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-09-12 | PordenonevParmaSerie B · Italy | 0–4 | Serie B · Italy |
| 2021-09-12 | RennesvReimsLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-09-12 | CosenzavVicenzaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-09-12 | NantesvNiceLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-09-12 | RegensburgvNurnberg2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-09-12 | LeedsvLiverpoolPremier League · England | 0–3 | Premier League · England |
| 2021-09-12 | CadizvSociedadLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-09-12 | SandefjordvValerengaEliteserien · Norway | 3–0 | Eliteserien · Norway |
| 2021-09-12 | FC DallasvSan Jose EarthquakesMLS · United States | 1–1 | MLS · United States |
| 2021-09-12 | FenerbahcevSivassporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-09-12 | BordeauxvLensLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-09-12 | Arsenal TulavCSKA MoscowPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-09-12 | SantosvBahiaSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-09-12 | FortalezavAtletico-MGSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-09-12 | Nott'm ForestvCardiffChampionship · England | 1–2 | Championship · England |
| 2021-09-12 | Ein FrankfurtvStuttgartBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-09-12 | M'gladbachvBielefeldBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-09-12 | Erzgebirge AuevFortuna Dusseldorf2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-09-12 | GroningenvHeerenveenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-09-12 | Randers FCvFC CopenhagenSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2021-09-12 | Volos NFCvLamiaSuper League · Greece | 2–1 | Super League · Greece |
| 2021-09-12 | AltachvRiedBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-09-12 | DjurgardenvHammarbyAllsvenskan · Sweden | 4–1 | Allsvenskan · Sweden |
| 2021-09-12 | CremonesevCittadellaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-09-12 | RizesporvHataysporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-09-11 | Kelty HeartsvElginLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-09-11 | AZ AlkmaarvPSV EindhovenEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2021-09-11 |  MonacovMarseilleLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-09-11 | PanetolikosvAsteras TripolisSuper League · Greece | 0–0 | Super League · Greece |
| 2021-09-11 | IpswichvBoltonLeague One · England | 2–5 | League One · England |
| 2021-09-11 | PlymouthvSheffield WedsLeague One · England | 3–0 | League One · England |
| 2021-09-11 | NapolivJuventusSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-09-11 | IlvesvLahtiVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2021-09-11 | DunkerquevNancyLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-09-11 | Santa ClaravBenficaPrimeira Liga · Portugal | 0–5 | Primeira Liga · Portugal |
| 2021-09-11 | Bristol CityvPrestonChampionship · England | 0–0 | Championship · England |
| 2021-09-11 | LuzernvGrasshoppersSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-09-11 | AlessandriavBresciaSerie B · Italy | 1–3 | Serie B · Italy |
| 2021-09-11 | StirlingvForfarLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-09-11 | KarlsruhevHolstein Kiel2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-09-11 | KilmarnockvMortonChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-09-11 | Club TijuanavSantos LagunaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-09-11 | St MirrenvDundee UnitedPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-09-11 | Spartak MoscowvKhimkiPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-09-11 | FrosinonevPerugiaSerie B · Italy | 0–0 | Serie B · Italy |