| 2021-12-12 | Wisla PlockvLegiaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-12-12 | Austria ViennavLASKBundesliga · Austria | 2–3 | Bundesliga · Austria |
| 2021-12-12 | Real MadridvAth MadridLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-12-12 | AngersvClermontLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-12-12 | Lokomotiv MoscowvUfaPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-12-12 | VitessevHeraclesEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-12-12 | ServettevBaselSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-12-12 | Club BruggevWaregemPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-12-12 | Crystal PalacevEvertonPremier League · England | 3–1 | Premier League · England |
| 2021-12-12 | Gornik Z.vPogon SzczecinEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-12-12 | LeganesvPonferradinaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-12-12 | NapolivEmpoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-12-12 | KarlsruhevHeidenheim2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-12-12 | Young BoysvSionSuper League · Switzerland | 4–3 | Super League · Switzerland |
| 2021-12-12 | PortovSp BragaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-12-12 | Paris SGv MonacoLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-12-12 | Ad. DemirsporvGiresunsporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-12-12 | Boca JuniorsvCentral CordobaLiga Profesional · Argentina | 8–1 | Liga Profesional · Argentina |
| 2021-12-12 | BesiktasvKayserisporSüper Lig · Turkey | 4–2 | Süper Lig · Turkey |
| 2021-12-12 | BrannvSarpsborg 08Eliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-12-12 |  Vietnamv MalaysiaAFF Championship | 3–0 | AFF Championship |
| 2021-12-12 | KrasnodarvPari NNPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-12-12 | SassuolovLazioSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-12-12 | HeartsvRangersPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2021-12-12 | Tianjin Jinmen TigervChongqing Liangjiang AthleticSuper League · China | 1–1 | Super League · China |
| 2021-12-12 | CFR ClujvMioveniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-12-12 | TorinovBolognaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-12-12 | OddvStabaekEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-12-12 | AlcorconvCartagenaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-12-12 | Dynamo MoscowvZenitPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-12-12 | GrasshoppersvLuzernSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-12-12 | BetisvSociedadLa Liga · Spain | 4–0 | La Liga · Spain |
| 2021-12-12 | ValladolidvOviedoLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-12-12 | AmorebietavLas PalmasLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-12-12 | MjondalenvBodo/GlimtEliteserien · Norway | 0–3 | Eliteserien · Norway |
| 2021-12-12 | GroningenvFeyenoordEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-12-12 | Defensa y JusticiavLanusLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-12-12 | HamburgvHansa Rostock2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-12-12 | VeronavAtalantaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-12-12 | AdmiravSK RapidBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2021-12-12 | ParmavPerugiaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-12-12 | NijmegenvPSV EindhovenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-12-12 | VicenzavComoSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-12-12 | Shanghai ShenhuavQingdao FCSuper League · China | 3–0 | Super League · China |
| 2021-12-12 | HaugesundvMoldeEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-12-12 |  Laosv IndonesiaAFF Championship | 1–5 | AFF Championship |
| 2021-12-12 | CelticvMotherwellPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-12-12 | TwentevWaalwijkEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-12-12 | BurnleyvWest HamPremier League · England | 0–0 | Premier League · England |
| 2021-12-12 | Sepsi Sf. GheorghevFarul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |