| 2024-10-20 | Minnesota UnitedvSt. Louis CityMLS · United States | 4–1 | MLS · United States |
| 2024-10-06 | St. Louis CityvHouston DynamoMLS · United States | 3–0 | MLS · United States |
| 2024-10-03 | Los Angeles FCvSt. Louis CityMLS · United States | 1–0 | MLS · United States |
| 2024-09-29 | St. Louis CityvSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2024-09-22 | San Jose EarthquakesvSt. Louis CityMLS · United States | 1–2 | MLS · United States |
| 2024-09-15 | St. Louis CityvMinnesota UnitedMLS · United States | 1–3 | MLS · United States |
| 2024-09-08 | New England RevolutionvSt. Louis CityMLS · United States | 2–2 | MLS · United States |
| 2024-09-01 | St. Louis CityvLos Angeles GalaxyMLS · United States | 2–1 | MLS · United States |
| 2024-08-25 | Portland TimbersvSt. Louis CityMLS · United States | 4–4 | MLS · United States |
| 2024-07-21 | Sporting Kansas CityvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2024-07-18 | Seattle SoundersvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2024-07-14 | St. Louis CityvVancouver WhitecapsMLS · United States | 1–4 | MLS · United States |
| 2024-07-08 | Colorado RapidsvSt. Louis CityMLS · United States | 4–1 | MLS · United States |
| 2024-07-04 | St. Louis CityvSan Jose EarthquakesMLS · United States | 2–0 | MLS · United States |
| 2024-06-30 | Vancouver WhitecapsvSt. Louis CityMLS · United States | 4–3 | MLS · United States |
| 2024-06-23 | St. Louis CityvAtlanta UtdMLS · United States | 1–1 | MLS · United States |
| 2024-06-20 | St. Louis CityvColorado RapidsMLS · United States | 0–3 | MLS · United States |
| 2024-06-16 | FC DallasvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2024-06-09 | St. Louis CityvPortland TimbersMLS · United States | 0–0 | MLS · United States |
| 2024-06-02 | Inter MiamivSt. Louis CityMLS · United States | 3–3 | MLS · United States |
| 2024-05-26 | St. Louis CityvSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2024-05-19 | FC CincinnativSt. Louis CityMLS · United States | 3–1 | MLS · United States |
| 2024-05-16 | St. Louis CityvLos Angeles FCMLS · United States | 0–2 | MLS · United States |
| 2024-05-12 | St. Louis CityvChicago FireMLS · United States | 3–1 | MLS · United States |
| 2024-05-05 | Houston DynamovSt. Louis CityMLS · United States | 0–0 | MLS · United States |
| 2024-04-21 | Sporting Kansas CityvSt. Louis CityMLS · United States | 3–3 | MLS · United States |
| 2024-04-14 | St. Louis CityvAustin FCMLS · United States | 1–0 | MLS · United States |
| 2024-04-07 | St. Louis CityvFC DallasMLS · United States | 0–0 | MLS · United States |
| 2024-03-31 | Real Salt LakevSt. Louis CityMLS · United States | 3–1 | MLS · United States |
| 2024-03-24 | St. Louis CityvDC UnitedMLS · United States | 2–2 | MLS · United States |
| 2024-03-17 | Los Angeles GalaxyvSt. Louis CityMLS · United States | 3–3 | MLS · United States |
| 2024-03-10 | Austin FCvSt. Louis CityMLS · United States | 2–2 | MLS · United States |
| 2024-03-03 | St. Louis CityvNew York CityMLS · United States | 2–0 | MLS · United States |
| 2024-02-25 | St. Louis CityvReal Salt LakeMLS · United States | 1–1 | MLS · United States |