| 2022-10-09 | Seattle SoundersvSan Jose EarthquakesMLS · United States | 2–2 | MLS · United States |
| 2022-10-02 | Sporting Kansas CityvSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-09-28 | Seattle SoundersvFC CincinnatiMLS · United States | 1–1 | MLS · United States |
| 2022-09-18 | Vancouver WhitecapsvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-09-11 | Seattle SoundersvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2022-09-05 | Seattle SoundersvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-09-01 | Orlando CityvSeattle SoundersMLS · United States | 3–2 | MLS · United States |
| 2022-08-27 | Portland TimbersvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-08-20 | Los Angeles GalaxyvSeattle SoundersMLS · United States | 3–3 | MLS · United States |
| 2022-08-15 | Seattle SoundersvReal Salt LakeMLS · United States | 1–2 | MLS · United States |
| 2022-08-06 | Atlanta UtdvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-08-03 | Seattle SoundersvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2022-07-30 | Los Angeles FCvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-07-24 | Seattle SoundersvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2022-07-17 | Chicago FirevSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-07-14 | Nashville SCvSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-07-09 | Seattle SoundersvPortland TimbersMLS · United States | 0–3 | MLS · United States |
| 2022-07-03 | Toronto FCvSeattle SoundersMLS · United States | 0–2 | MLS · United States |
| 2022-06-30 | Seattle SoundersvCF MontrealMLS · United States | 1–2 | MLS · United States |
| 2022-06-25 | Seattle SoundersvSporting Kansas CityMLS · United States | 3–0 | MLS · United States |
| 2022-06-18 | Seattle SoundersvLos Angeles FCMLS · United States | 1–1 | MLS · United States |
| 2022-06-15 | Seattle SoundersvVancouver WhitecapsMLS · United States | 4–0 | MLS · United States |
| 2022-05-30 | Seattle SoundersvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-05-23 | Colorado RapidsvSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-05-19 | Houston DynamovSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2022-05-15 | Seattle SoundersvMinnesota UnitedMLS · United States | 3–1 | MLS · United States |
| 2022-05-08 | FC DallasvSeattle SoundersMLS · United States | 2–0 | MLS · United States |
| 2022-04-24 | San Jose EarthquakesvSeattle SoundersMLS · United States | 4–3 | MLS · United States |
| 2022-04-17 | Seattle SoundersvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-04-03 | Minnesota UnitedvSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2022-03-20 | Austin FCvSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2022-03-12 | Seattle SoundersvLos Angeles GalaxyMLS · United States | 3–2 | MLS · United States |
| 2022-03-05 | Real Salt LakevSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-02-28 | Seattle SoundersvNashville SCMLS · United States | 0–1 | MLS · United States |