| 2021-11-07 | San Jose EarthquakesvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2021-10-30 | Real Salt LakevSan Jose EarthquakesMLS · United States | 3–4 | MLS · United States |
| 2021-10-28 | Portland TimbersvSan Jose EarthquakesMLS · United States | 2–0 | MLS · United States |
| 2021-10-24 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-10-21 | San Jose EarthquakesvAustin FCMLS · United States | 4–0 | MLS · United States |
| 2021-10-16 | Los Angeles FCvSan Jose EarthquakesMLS · United States | 3–1 | MLS · United States |
| 2021-10-03 | Vancouver WhitecapsvSan Jose EarthquakesMLS · United States | 3–0 | MLS · United States |
| 2021-09-30 | San Jose EarthquakesvSeattle SoundersMLS · United States | 1–3 | MLS · United States |
| 2021-09-26 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–0 | MLS · United States |
| 2021-09-19 | Austin FCvSan Jose EarthquakesMLS · United States | 3–4 | MLS · United States |
| 2021-09-16 | San Jose EarthquakesvReal Salt LakeMLS · United States | 3–4 | MLS · United States |
| 2021-09-12 | FC DallasvSan Jose EarthquakesMLS · United States | 1–1 | MLS · United States |
| 2021-09-05 | San Jose EarthquakesvColorado RapidsMLS · United States | 0–1 | MLS · United States |
| 2021-08-21 | Los Angeles GalaxyvSan Jose EarthquakesMLS · United States | 1–2 | MLS · United States |
| 2021-08-18 | San Jose EarthquakesvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |
| 2021-08-14 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2021-08-09 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2021-08-05 | Portland TimbersvSan Jose EarthquakesMLS · United States | 1–1 | MLS · United States |
| 2021-07-31 | Seattle SoundersvSan Jose EarthquakesMLS · United States | 0–1 | MLS · United States |
| 2021-07-25 | San Jose EarthquakesvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2021-07-22 | Sporting Kansas CityvSan Jose EarthquakesMLS · United States | 1–1 | MLS · United States |
| 2021-07-18 | Colorado RapidsvSan Jose EarthquakesMLS · United States | 1–1 | MLS · United States |
| 2021-07-04 | Minnesota UnitedvSan Jose EarthquakesMLS · United States | 2–2 | MLS · United States |
| 2021-06-27 | San Jose EarthquakesvLos Angeles GalaxyMLS · United States | 1–3 | MLS · United States |
| 2021-06-23 | Orlando CityvSan Jose EarthquakesMLS · United States | 5–0 | MLS · United States |
| 2021-06-20 | Austin FCvSan Jose EarthquakesMLS · United States | 0–0 | MLS · United States |
| 2021-05-30 | Los Angeles GalaxyvSan Jose EarthquakesMLS · United States | 1–0 | MLS · United States |
| 2021-05-23 | San Jose EarthquakesvSporting Kansas CityMLS · United States | 1–3 | MLS · United States |
| 2021-05-16 | San Jose EarthquakesvPortland TimbersMLS · United States | 0–2 | MLS · United States |
| 2021-05-13 | San Jose EarthquakesvSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2021-05-08 | Real Salt LakevSan Jose EarthquakesMLS · United States | 1–2 | MLS · United States |
| 2021-05-02 | San Jose EarthquakesvDC UnitedMLS · United States | 4–1 | MLS · United States |
| 2021-04-24 | San Jose EarthquakesvFC DallasMLS · United States | 3–1 | MLS · United States |
| 2021-04-17 | Houston DynamovSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |