| 2022-11-05 | Los Angeles FCvPhiladelphia UnionMLS · United States | 3–3 | MLS · United States |
| 2022-10-31 | Philadelphia UnionvNew York CityMLS · United States | 3–1 | MLS · United States |
| 2022-10-21 | Philadelphia UnionvFC CincinnatiMLS · United States | 1–0 | MLS · United States |
| 2022-10-09 | Philadelphia UnionvToronto FCMLS · United States | 4–0 | MLS · United States |
| 2022-10-01 | CharlottevPhiladelphia UnionMLS · United States | 4–0 | MLS · United States |
| 2022-09-17 | Atlanta UtdvPhiladelphia UnionMLS · United States | 0–0 | MLS · United States |
| 2022-09-11 | Philadelphia UnionvOrlando CityMLS · United States | 5–1 | MLS · United States |
| 2022-09-04 | New York Red BullsvPhiladelphia UnionMLS · United States | 0–2 | MLS · United States |
| 2022-09-01 | Philadelphia UnionvAtlanta UtdMLS · United States | 4–1 | MLS · United States |
| 2022-08-28 | Philadelphia UnionvColorado RapidsMLS · United States | 6–0 | MLS · United States |
| 2022-08-21 | DC UnitedvPhiladelphia UnionMLS · United States | 0–6 | MLS · United States |
| 2022-08-18 | FC DallasvPhiladelphia UnionMLS · United States | 1–0 | MLS · United States |
| 2022-08-14 | Philadelphia UnionvChicago FireMLS · United States | 4–1 | MLS · United States |
| 2022-08-07 | FC CincinnativPhiladelphia UnionMLS · United States | 3–1 | MLS · United States |
| 2022-07-31 | Philadelphia UnionvHouston DynamoMLS · United States | 6–0 | MLS · United States |
| 2022-07-24 | Orlando CityvPhiladelphia UnionMLS · United States | 0–1 | MLS · United States |
| 2022-07-17 | Philadelphia UnionvNew England RevolutionMLS · United States | 2–1 | MLS · United States |
| 2022-07-14 | Inter MiamivPhiladelphia UnionMLS · United States | 1–2 | MLS · United States |
| 2022-07-09 | Philadelphia UnionvDC UnitedMLS · United States | 7–0 | MLS · United States |
| 2022-07-04 | Columbus CrewvPhiladelphia UnionMLS · United States | 0–0 | MLS · United States |
| 2022-06-30 | Chicago FirevPhiladelphia UnionMLS · United States | 1–0 | MLS · United States |
| 2022-06-26 | Philadelphia UnionvNew York CityMLS · United States | 2–1 | MLS · United States |
| 2022-06-19 | Philadelphia UnionvFC CincinnatiMLS · United States | 1–1 | MLS · United States |
| 2022-05-29 | New England RevolutionvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2022-05-23 | Portland TimbersvPhiladelphia UnionMLS · United States | 0–2 | MLS · United States |
| 2022-05-19 | Philadelphia UnionvInter MiamiMLS · United States | 0–0 | MLS · United States |
| 2022-05-15 | Philadelphia UnionvNew York Red BullsMLS · United States | 1–1 | MLS · United States |
| 2022-05-08 | Los Angeles FCvPhiladelphia UnionMLS · United States | 2–2 | MLS · United States |
| 2022-05-01 | Nashville SCvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2022-04-23 | Philadelphia UnionvCF MontrealMLS · United States | 1–1 | MLS · United States |
| 2022-04-17 | Toronto FCvPhiladelphia UnionMLS · United States | 2–1 | MLS · United States |
| 2022-04-09 | Philadelphia UnionvColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2022-04-03 | Philadelphia UnionvCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-03-19 | New York CityvPhiladelphia UnionMLS · United States | 0–2 | MLS · United States |
| 2022-03-13 | Philadelphia UnionvSan Jose EarthquakesMLS · United States | 2–0 | MLS · United States |
| 2022-03-05 | CF MontrealvPhiladelphia UnionMLS · United States | 1–2 | MLS · United States |
| 2022-02-26 | Philadelphia UnionvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |