| 2022-10-18 | FC DallasvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |
| 2022-10-09 | Minnesota UnitedvVancouver WhitecapsMLS · United States | 2–0 | MLS · United States |
| 2022-10-02 | San Jose EarthquakesvMinnesota UnitedMLS · United States | 2–0 | MLS · United States |
| 2022-09-18 | Sporting Kansas CityvMinnesota UnitedMLS · United States | 4–1 | MLS · United States |
| 2022-09-14 | Minnesota UnitedvLos Angeles FCMLS · United States | 1–1 | MLS · United States |
| 2022-09-11 | Portland TimbersvMinnesota UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-09-03 | Minnesota UnitedvFC DallasMLS · United States | 0–3 | MLS · United States |
| 2022-09-01 | Real Salt LakevMinnesota UnitedMLS · United States | 3–0 | MLS · United States |
| 2022-08-27 | Minnesota UnitedvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-08-21 | Minnesota UnitedvAustin FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-15 | Nashville SCvMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2022-08-07 | Colorado RapidsvMinnesota UnitedMLS · United States | 4–3 | MLS · United States |
| 2022-07-30 | Minnesota UnitedvPortland TimbersMLS · United States | 4–4 | MLS · United States |
| 2022-07-24 | Houston DynamovMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2022-07-17 | Minnesota UnitedvDC UnitedMLS · United States | 2–0 | MLS · United States |
| 2022-07-14 | Minnesota UnitedvSporting Kansas CityMLS · United States | 1–1 | MLS · United States |
| 2022-07-09 | Vancouver WhitecapsvMinnesota UnitedMLS · United States | 1–3 | MLS · United States |
| 2022-07-04 | Minnesota UnitedvReal Salt LakeMLS · United States | 3–2 | MLS · United States |
| 2022-06-30 | Los Angeles GalaxyvMinnesota UnitedMLS · United States | 2–3 | MLS · United States |
| 2022-06-26 | Inter MiamivMinnesota UnitedMLS · United States | 2–1 | MLS · United States |
| 2022-06-19 | New England RevolutionvMinnesota UnitedMLS · United States | 2–1 | MLS · United States |
| 2022-05-29 | Minnesota UnitedvNew York CityMLS · United States | 0–1 | MLS · United States |
| 2022-05-23 | FC DallasvMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2022-05-19 | Minnesota UnitedvLos Angeles GalaxyMLS · United States | 1–1 | MLS · United States |
| 2022-05-15 | Seattle SoundersvMinnesota UnitedMLS · United States | 3–1 | MLS · United States |
| 2022-05-08 | Minnesota UnitedvFC CincinnatiMLS · United States | 0–1 | MLS · United States |
| 2022-05-02 | Los Angeles FCvMinnesota UnitedMLS · United States | 2–0 | MLS · United States |
| 2022-04-23 | Minnesota UnitedvChicago FireMLS · United States | 3–0 | MLS · United States |
| 2022-04-17 | Minnesota UnitedvColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2022-04-11 | Austin FCvMinnesota UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-04-03 | Minnesota UnitedvSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2022-03-20 | Minnesota UnitedvSan Jose EarthquakesMLS · United States | 1–0 | MLS · United States |
| 2022-03-13 | New York Red BullsvMinnesota UnitedMLS · United States | 0–1 | MLS · United States |
| 2022-03-05 | Minnesota UnitedvNashville SCMLS · United States | 1–1 | MLS · United States |
| 2022-02-26 | Philadelphia UnionvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |