| 2022-11-05 | Los Angeles FCvPhiladelphia UnionMLS · United States | 3–3 | MLS · United States |
| 2022-10-30 | Los Angeles FCvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2022-10-21 | Los Angeles FCvLos Angeles GalaxyMLS · United States | 3–2 | MLS · United States |
| 2022-10-09 | Los Angeles FCvNashville SCMLS · United States | 0–1 | MLS · United States |
| 2022-10-02 | Portland TimbersvLos Angeles FCMLS · United States | 1–2 | MLS · United States |
| 2022-09-19 | Los Angeles FCvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2022-09-14 | Minnesota UnitedvLos Angeles FCMLS · United States | 1–1 | MLS · United States |
| 2022-09-11 | FC DallasvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-09-05 | Los Angeles FCvReal Salt LakeMLS · United States | 2–0 | MLS · United States |
| 2022-09-01 | Houston DynamovLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-27 | Austin FCvLos Angeles FCMLS · United States | 4–1 | MLS · United States |
| 2022-08-21 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-17 | Los Angeles FCvDC UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-08-14 | Los Angeles FCvCharlotteMLS · United States | 5–0 | MLS · United States |
| 2022-08-07 | Real Salt LakevLos Angeles FCMLS · United States | 1–4 | MLS · United States |
| 2022-07-30 | Los Angeles FCvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-07-24 | Sporting Kansas CityvLos Angeles FCMLS · United States | 0–2 | MLS · United States |
| 2022-07-18 | Nashville SCvLos Angeles FCMLS · United States | 1–2 | MLS · United States |
| 2022-07-09 | Los Angeles FCvLos Angeles GalaxyMLS · United States | 3–2 | MLS · United States |
| 2022-07-03 | Vancouver WhitecapsvLos Angeles FCMLS · United States | 1–0 | MLS · United States |
| 2022-06-30 | Los Angeles FCvFC DallasMLS · United States | 3–1 | MLS · United States |
| 2022-06-26 | Los Angeles FCvNew York Red BullsMLS · United States | 2–0 | MLS · United States |
| 2022-06-18 | Seattle SoundersvLos Angeles FCMLS · United States | 1–1 | MLS · United States |
| 2022-05-28 | Los Angeles FCvSan Jose EarthquakesMLS · United States | 3–2 | MLS · United States |
| 2022-05-21 | Columbus CrewvLos Angeles FCMLS · United States | 0–2 | MLS · United States |
| 2022-05-19 | Los Angeles FCvAustin FCMLS · United States | 1–2 | MLS · United States |
| 2022-05-14 | Colorado RapidsvLos Angeles FCMLS · United States | 2–0 | MLS · United States |
| 2022-05-08 | Los Angeles FCvPhiladelphia UnionMLS · United States | 2–2 | MLS · United States |
| 2022-05-02 | Los Angeles FCvMinnesota UnitedMLS · United States | 2–0 | MLS · United States |
| 2022-04-24 | FC CincinnativLos Angeles FCMLS · United States | 1–2 | MLS · United States |
| 2022-04-17 | Los Angeles FCvSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2022-04-10 | Los Angeles GalaxyvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-04-03 | Orlando CityvLos Angeles FCMLS · United States | 2–4 | MLS · United States |
| 2022-03-21 | Los Angeles FCvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2022-03-12 | Inter MiamivLos Angeles FCMLS · United States | 0–2 | MLS · United States |
| 2022-03-07 | Los Angeles FCvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2022-02-26 | Los Angeles FCvColorado RapidsMLS · United States | 3–0 | MLS · United States |