| 2022-10-18 | New York CityvInter MiamiMLS · United States | 3–0 | MLS · United States |
| 2022-10-09 | Inter MiamivCF MontrealMLS · United States | 1–3 | MLS · United States |
| 2022-10-06 | Inter MiamivOrlando CityMLS · United States | 4–1 | MLS · United States |
| 2022-10-01 | Toronto FCvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-09-18 | DC UnitedvInter MiamiMLS · United States | 2–3 | MLS · United States |
| 2022-09-14 | Inter MiamivColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2022-09-11 | Chicago FirevInter MiamiMLS · United States | 3–1 | MLS · United States |
| 2022-09-01 | Columbus CrewvInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-08-28 | New York Red BullsvInter MiamiMLS · United States | 3–1 | MLS · United States |
| 2022-08-21 | Inter MiamivToronto FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-14 | Inter MiamivNew York CityMLS · United States | 3–2 | MLS · United States |
| 2022-08-07 | CF MontrealvInter MiamiMLS · United States | 2–2 | MLS · United States |
| 2022-08-04 | San Jose EarthquakesvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-07-31 | Inter MiamivFC CincinnatiMLS · United States | 4–4 | MLS · United States |
| 2022-07-24 | New York CityvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2022-07-17 | Inter MiamivCharlotteMLS · United States | 3–2 | MLS · United States |
| 2022-07-14 | Inter MiamivPhiladelphia UnionMLS · United States | 1–2 | MLS · United States |
| 2022-07-10 | Orlando CityvInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-07-05 | FC DallasvInter MiamiMLS · United States | 1–1 | MLS · United States |
| 2022-06-26 | Inter MiamivMinnesota UnitedMLS · United States | 2–1 | MLS · United States |
| 2022-06-19 | Atlanta UtdvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2022-05-29 | Inter MiamivPortland TimbersMLS · United States | 2–1 | MLS · United States |
| 2022-05-22 | Inter MiamivNew York Red BullsMLS · United States | 2–0 | MLS · United States |
| 2022-05-19 | Philadelphia UnionvInter MiamiMLS · United States | 0–0 | MLS · United States |
| 2022-05-15 | Inter MiamivDC UnitedMLS · United States | 2–2 | MLS · United States |
| 2022-05-07 | CharlottevInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-05-01 | New England RevolutionvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2022-04-24 | Inter MiamivAtlanta UtdMLS · United States | 2–1 | MLS · United States |
| 2022-04-17 | Seattle SoundersvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-04-09 | Inter MiamivNew England RevolutionMLS · United States | 3–2 | MLS · United States |
| 2022-04-03 | Inter MiamivHouston DynamoMLS · United States | 1–3 | MLS · United States |
| 2022-03-19 | FC CincinnativInter MiamiMLS · United States | 3–1 | MLS · United States |
| 2022-03-12 | Inter MiamivLos Angeles FCMLS · United States | 0–2 | MLS · United States |
| 2022-03-06 | Austin FCvInter MiamiMLS · United States | 5–1 | MLS · United States |
| 2022-02-26 | Inter MiamivChicago FireMLS · United States | 0–0 | MLS · United States |