| 2025-10-19 | Sporting Kansas CityvHouston DynamoMLS · United States | 0–0 | MLS · United States |
| 2025-10-05 | Houston DynamovSan Diego FCMLS · United States | 2–4 | MLS · United States |
| 2025-09-28 | Nashville SCvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2025-09-21 | Houston DynamovPortland TimbersMLS · United States | 1–0 | MLS · United States |
| 2025-09-14 | Colorado RapidsvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2025-09-07 | Houston DynamovLos Angeles GalaxyMLS · United States | 1–1 | MLS · United States |
| 2025-08-31 | St. Louis CityvHouston DynamoMLS · United States | 2–3 | MLS · United States |
| 2025-08-24 | Houston DynamovSan Jose EarthquakesMLS · United States | 1–2 | MLS · United States |
| 2025-08-18 | Vancouver WhitecapsvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2025-08-10 | Austin FCvHouston DynamoMLS · United States | 2–2 | MLS · United States |
| 2025-07-20 | Houston DynamovPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2025-07-17 | Houston DynamovVancouver WhitecapsMLS · United States | 0–3 | MLS · United States |
| 2025-07-13 | Real Salt LakevHouston DynamoMLS · United States | 1–0 | MLS · United States |
| 2025-07-06 | San Diego FCvHouston DynamoMLS · United States | 3–4 | MLS · United States |
| 2025-06-29 | Houston DynamovSt. Louis CityMLS · United States | 1–0 | MLS · United States |
| 2025-06-26 | Minnesota UnitedvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2025-06-15 | Houston DynamovCF MontrealMLS · United States | 1–3 | MLS · United States |
| 2025-06-01 | Houston DynamovSporting Kansas CityMLS · United States | 1–3 | MLS · United States |
| 2025-05-29 | New York CityvHouston DynamoMLS · United States | 0–3 | MLS · United States |
| 2025-05-25 | San Jose EarthquakesvHouston DynamoMLS · United States | 3–3 | MLS · United States |
| 2025-05-18 | FC DallasvHouston DynamoMLS · United States | 0–2 | MLS · United States |
| 2025-05-15 | Houston DynamovMinnesota UnitedMLS · United States | 2–0 | MLS · United States |
| 2025-05-11 | Houston DynamovSeattle SoundersMLS · United States | 1–3 | MLS · United States |
| 2025-05-04 | Los Angeles FCvHouston DynamoMLS · United States | 2–0 | MLS · United States |
| 2025-04-27 | Houston DynamovAustin FCMLS · United States | 2–0 | MLS · United States |
| 2025-04-20 | Houston DynamovColorado RapidsMLS · United States | 2–2 | MLS · United States |
| 2025-04-13 | Los Angeles GalaxyvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2025-04-06 | Houston DynamovLos Angeles FCMLS · United States | 1–0 | MLS · United States |
| 2025-03-31 | Portland TimbersvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2025-03-23 | Seattle SoundersvHouston DynamoMLS · United States | 0–0 | MLS · United States |
| 2025-03-16 | Houston DynamovReal Salt LakeMLS · United States | 1–2 | MLS · United States |
| 2025-03-08 | Columbus CrewvHouston DynamoMLS · United States | 0–0 | MLS · United States |
| 2025-03-03 | Houston DynamovInter MiamiMLS · United States | 1–4 | MLS · United States |
| 2025-02-23 | Houston DynamovFC DallasMLS · United States | 1–2 | MLS · United States |