| 2022-10-09 | Houston DynamovLos Angeles GalaxyMLS · United States | 1–3 | MLS · United States |
| 2022-10-03 | Nashville SCvHouston DynamoMLS · United States | 1–2 | MLS · United States |
| 2022-09-19 | Los Angeles FCvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2022-09-14 | Houston DynamovNew England RevolutionMLS · United States | 3–1 | MLS · United States |
| 2022-09-11 | Houston DynamovSporting Kansas CityMLS · United States | 0–0 | MLS · United States |
| 2022-09-05 | Seattle SoundersvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-09-01 | Houston DynamovLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-27 | Minnesota UnitedvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-08-21 | Colorado RapidsvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2022-08-14 | Houston DynamovCF MontrealMLS · United States | 2–3 | MLS · United States |
| 2022-08-06 | Vancouver WhitecapsvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-07-31 | Philadelphia UnionvHouston DynamoMLS · United States | 6–0 | MLS · United States |
| 2022-07-24 | Houston DynamovMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2022-07-18 | San Jose EarthquakesvHouston DynamoMLS · United States | 1–2 | MLS · United States |
| 2022-07-13 | Austin FCvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2022-07-10 | Houston DynamovFC DallasMLS · United States | 2–2 | MLS · United States |
| 2022-07-04 | Houston DynamovCharlotteMLS · United States | 1–2 | MLS · United States |
| 2022-06-30 | Portland TimbersvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-06-26 | Houston DynamovChicago FireMLS · United States | 2–0 | MLS · United States |
| 2022-06-19 | Orlando CityvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-05-29 | Real Salt LakevHouston DynamoMLS · United States | 3–0 | MLS · United States |
| 2022-05-23 | Los Angeles GalaxyvHouston DynamoMLS · United States | 0–3 | MLS · United States |
| 2022-05-19 | Houston DynamovSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2022-05-15 | Houston DynamovNashville SCMLS · United States | 2–0 | MLS · United States |
| 2022-05-08 | DC UnitedvHouston DynamoMLS · United States | 2–0 | MLS · United States |
| 2022-04-30 | Houston DynamovAustin FCMLS · United States | 1–2 | MLS · United States |
| 2022-04-23 | FC DallasvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-04-16 | Houston DynamovPortland TimbersMLS · United States | 0–0 | MLS · United States |
| 2022-04-10 | Houston DynamovSan Jose EarthquakesMLS · United States | 4–3 | MLS · United States |
| 2022-04-03 | Inter MiamivHouston DynamoMLS · United States | 1–3 | MLS · United States |
| 2022-03-20 | Houston DynamovColorado RapidsMLS · United States | 1–1 | MLS · United States |
| 2022-03-12 | Houston DynamovVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-03-05 | Sporting Kansas CityvHouston DynamoMLS · United States | 1–0 | MLS · United States |
| 2022-02-28 | Houston DynamovReal Salt LakeMLS · United States | 0–0 | MLS · United States |