| 2026-09-13 | Columbus CrewvNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2026-09-10 | DC UnitedvColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2026-09-06 | Columbus CrewvColorado RapidsMLS · United States | 3–0 | MLS · United States |
| 2026-08-30 | Columbus CrewvNew England RevolutionMLS · United States | 1–3 | MLS · United States |
| 2026-08-23 | Nashville SCvColumbus CrewMLS · United States | 3–2 | MLS · United States |
| 2026-08-20 | Columbus CrewvCF MontrealMLS · United States | 1–2 | MLS · United States |
| 2026-08-16 | CharlottevColumbus CrewMLS · United States | 3–1 | MLS · United States |
| 2026-08-02 | Inter MiamivColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2026-07-26 | Columbus CrewvFC CincinnatiMLS · United States | 2–1 | MLS · United States |
| 2026-07-23 | Columbus CrewvNew York CityMLS · United States | 1–2 | MLS · United States |
| 2026-05-24 | Columbus CrewvAtlanta UtdMLS · United States | 2–0 | MLS · United States |
| 2026-05-17 | Philadelphia UnionvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2026-05-14 | New York Red BullsvColumbus CrewMLS · United States | 3–2 | MLS · United States |
| 2026-05-10 | New York CityvColumbus CrewMLS · United States | 3–0 | MLS · United States |
| 2026-05-03 | Columbus CrewvMinnesota UnitedMLS · United States | 2–3 | MLS · United States |
| 2026-04-26 | Columbus CrewvPhiladelphia UnionMLS · United States | 2–0 | MLS · United States |
| 2026-04-23 | Columbus CrewvLos Angeles GalaxyMLS · United States | 2–1 | MLS · United States |
| 2026-04-19 | New England RevolutionvColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2026-04-13 | Columbus CrewvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2026-04-05 | Atlanta UtdvColumbus CrewMLS · United States | 1–3 | MLS · United States |
| 2026-03-21 | Toronto FCvColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2026-03-14 | Columbus CrewvNashville SCMLS · United States | 0–1 | MLS · United States |
| 2026-03-08 | Columbus CrewvChicago FireMLS · United States | 0–0 | MLS · United States |
| 2026-03-01 | Sporting Kansas CityvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2026-02-22 | Portland TimbersvColumbus CrewMLS · United States | 3–2 | MLS · United States |