| 2022-10-09 | Austin FCvColorado RapidsMLS · United States | 1–1 | MLS · United States |
| 2022-10-01 | Colorado RapidsvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2022-09-18 | Los Angeles GalaxyvColorado RapidsMLS · United States | 4–1 | MLS · United States |
| 2022-09-15 | Colorado RapidsvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2022-09-11 | Colorado RapidsvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2022-09-05 | DC UnitedvColorado RapidsMLS · United States | 0–0 | MLS · United States |
| 2022-09-01 | Nashville SCvColorado RapidsMLS · United States | 4–1 | MLS · United States |
| 2022-08-28 | Philadelphia UnionvColorado RapidsMLS · United States | 6–0 | MLS · United States |
| 2022-08-21 | Colorado RapidsvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2022-08-18 | Vancouver WhitecapsvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2022-08-14 | Colorado RapidsvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2022-08-07 | Colorado RapidsvMinnesota UnitedMLS · United States | 4–3 | MLS · United States |
| 2022-08-03 | New York Red BullsvColorado RapidsMLS · United States | 4–5 | MLS · United States |
| 2022-07-24 | Seattle SoundersvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2022-07-17 | Colorado RapidsvLos Angeles GalaxyMLS · United States | 2–0 | MLS · United States |
| 2022-07-14 | Colorado RapidsvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2022-07-10 | Real Salt LakevColorado RapidsMLS · United States | 2–2 | MLS · United States |
| 2022-07-05 | Colorado RapidsvAustin FCMLS · United States | 2–3 | MLS · United States |
| 2022-06-26 | Portland TimbersvColorado RapidsMLS · United States | 3–0 | MLS · United States |
| 2022-06-19 | New York CityvColorado RapidsMLS · United States | 1–1 | MLS · United States |
| 2022-05-29 | Colorado RapidsvNashville SCMLS · United States | 1–3 | MLS · United States |
| 2022-05-23 | Colorado RapidsvSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-05-19 | Sporting Kansas CityvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2022-05-14 | Colorado RapidsvLos Angeles FCMLS · United States | 2–0 | MLS · United States |
| 2022-05-08 | San Jose EarthquakesvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2022-05-01 | Colorado RapidsvPortland TimbersMLS · United States | 2–0 | MLS · United States |
| 2022-04-24 | Colorado RapidsvCharlotteMLS · United States | 0–0 | MLS · United States |
| 2022-04-17 | Minnesota UnitedvColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2022-04-10 | FC DallasvColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2022-04-03 | Colorado RapidsvReal Salt LakeMLS · United States | 1–1 | MLS · United States |
| 2022-03-20 | Houston DynamovColorado RapidsMLS · United States | 1–1 | MLS · United States |
| 2022-03-13 | Colorado RapidsvSporting Kansas CityMLS · United States | 2–0 | MLS · United States |
| 2022-03-05 | Colorado RapidsvAtlanta UtdMLS · United States | 3–0 | MLS · United States |
| 2022-02-26 | Los Angeles FCvColorado RapidsMLS · United States | 3–0 | MLS · United States |