| 2021-08-19 | New England RevolutionvDC UnitedMLS · United States | 3–2 | MLS · United States |
| 2021-08-19 | Atlanta UtdvToronto FCMLS · United States | 1–0 | MLS · United States |
| 2021-08-19 | Nashville SCvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2021-08-19 | FC DallasvSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2021-08-19 | New York Red BullsvColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2021-08-19 | Sporting Kansas CityvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2021-08-19 | Austin FCvVancouver WhitecapsMLS · United States | 1–2 | MLS · United States |
| 2021-08-19 | Philadelphia UnionvNew York CityMLS · United States | 1–0 | MLS · United States |
| 2021-08-19 | Inter MiamivChicago FireMLS · United States | 3–2 | MLS · United States |
| 2021-08-19 | Real Salt LakevHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2021-08-18 | San Jose EarthquakesvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |
| 2021-08-18 | Los Angeles GalaxyvColorado RapidsMLS · United States | 1–2 | MLS · United States |
| 2021-08-16 | Nashville SCvDC UnitedMLS · United States | 5–2 | MLS · United States |
| 2021-08-16 | Portland TimbersvSeattle SoundersMLS · United States | 2–6 | MLS · United States |
| 2021-08-15 | New York CityvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2021-08-15 | Atlanta UtdvLos Angeles FCMLS · United States | 1–0 | MLS · United States |
| 2021-08-15 | CF MontrealvNew York Red BullsMLS · United States | 2–1 | MLS · United States |
| 2021-08-15 | FC DallasvSporting Kansas CityMLS · United States | 0–2 | MLS · United States |
| 2021-08-15 | Real Salt LakevAustin FCMLS · United States | 1–0 | MLS · United States |
| 2021-08-15 | Houston DynamovColorado RapidsMLS · United States | 1–3 | MLS · United States |
| 2021-08-15 | Toronto FCvNew England RevolutionMLS · United States | 1–2 | MLS · United States |
| 2021-08-15 | Chicago FirevColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2021-08-14 | Minnesota UnitedvLos Angeles GalaxyMLS · United States | 0–1 | MLS · United States |
| 2021-08-14 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2021-08-09 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2021-08-09 | DC UnitedvCF MontrealMLS · United States | 2–1 | MLS · United States |
| 2021-08-09 | Los Angeles GalaxyvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-08-08 | Columbus CrewvAtlanta UtdMLS · United States | 2–3 | MLS · United States |
| 2021-08-08 | Toronto FCvNew York CityMLS · United States | 2–2 | MLS · United States |
| 2021-08-08 | FC DallasvAustin FCMLS · United States | 2–0 | MLS · United States |
| 2021-08-08 | FC CincinnativOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2021-08-08 | Colorado RapidsvSporting Kansas CityMLS · United States | 0–0 | MLS · United States |
| 2021-08-08 | Portland TimbersvReal Salt LakeMLS · United States | 3–2 | MLS · United States |
| 2021-08-08 | New England RevolutionvPhiladelphia UnionMLS · United States | 2–1 | MLS · United States |
| 2021-08-08 | Minnesota UnitedvHouston DynamoMLS · United States | 2–0 | MLS · United States |
| 2021-08-08 | Chicago FirevNew York Red BullsMLS · United States | 2–1 | MLS · United States |
| 2021-08-08 | Inter MiamivNashville SCMLS · United States | 2–1 | MLS · United States |
| 2021-08-05 | Orlando CityvInter MiamiMLS · United States | 1–1 | MLS · United States |
| 2021-08-05 | Seattle SoundersvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2021-08-05 | Portland TimbersvSan Jose EarthquakesMLS · United States | 1–1 | MLS · United States |
| 2021-08-05 | Chicago FirevNew York CityMLS · United States | 0–0 | MLS · United States |
| 2021-08-05 | CF MontrealvAtlanta UtdMLS · United States | 2–2 | MLS · United States |
| 2021-08-05 | Columbus CrewvDC UnitedMLS · United States | 2–4 | MLS · United States |
| 2021-08-05 | New England RevolutionvNashville SCMLS · United States | 0–0 | MLS · United States |
| 2021-08-05 | New York Red BullsvFC CincinnatiMLS · United States | 0–0 | MLS · United States |
| 2021-08-05 | Los Angeles FCvSporting Kansas CityMLS · United States | 1–4 | MLS · United States |
| 2021-08-05 | Philadelphia UnionvToronto FCMLS · United States | 3–0 | MLS · United States |
| 2021-08-05 | Los Angeles GalaxyvReal Salt LakeMLS · United States | 1–0 | MLS · United States |
| 2021-08-05 | Austin FCvHouston DynamoMLS · United States | 3–2 | MLS · United States |
| 2021-08-02 | Toronto FCvNashville SCMLS · United States | 1–1 | MLS · United States |