| 2022-04-17 | New York Red BullsvFC DallasMLS · United States | 0–0 | MLS · United States |
| 2022-04-16 | Houston DynamovPortland TimbersMLS · United States | 0–0 | MLS · United States |
| 2022-04-16 | Atlanta UtdvFC CincinnatiMLS · United States | 0–0 | MLS · United States |
| 2022-04-16 | CF MontrealvVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-04-16 | San Jose EarthquakesvNashville SCMLS · United States | 2–2 | MLS · United States |
| 2022-04-11 | Austin FCvMinnesota UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-04-10 | Sporting Kansas CityvNashville SCMLS · United States | 1–2 | MLS · United States |
| 2022-04-10 | Vancouver WhitecapsvPortland TimbersMLS · United States | 2–3 | MLS · United States |
| 2022-04-10 | Real Salt LakevToronto FCMLS · United States | 2–2 | MLS · United States |
| 2022-04-10 | CharlottevAtlanta UtdMLS · United States | 1–0 | MLS · United States |
| 2022-04-10 | Houston DynamovSan Jose EarthquakesMLS · United States | 4–3 | MLS · United States |
| 2022-04-10 | FC DallasvColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2022-04-10 | Los Angeles GalaxyvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-04-09 | Orlando CityvChicago FireMLS · United States | 1–0 | MLS · United States |
| 2022-04-09 | Philadelphia UnionvColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2022-04-09 | New York Red BullsvCF MontrealMLS · United States | 1–2 | MLS · United States |
| 2022-04-09 | Inter MiamivNew England RevolutionMLS · United States | 3–2 | MLS · United States |
| 2022-04-03 | San Jose EarthquakesvAustin FCMLS · United States | 2–2 | MLS · United States |
| 2022-04-03 | Portland TimbersvLos Angeles GalaxyMLS · United States | 1–3 | MLS · United States |
| 2022-04-03 | Inter MiamivHouston DynamoMLS · United States | 1–3 | MLS · United States |
| 2022-04-03 | Minnesota UnitedvSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2022-04-03 | Orlando CityvLos Angeles FCMLS · United States | 2–4 | MLS · United States |
| 2022-04-03 | Colorado RapidsvReal Salt LakeMLS · United States | 1–1 | MLS · United States |
| 2022-04-03 | Vancouver WhitecapsvSporting Kansas CityMLS · United States | 1–0 | MLS · United States |
| 2022-04-03 | Philadelphia UnionvCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-04-03 | DC UnitedvAtlanta UtdMLS · United States | 0–1 | MLS · United States |
| 2022-04-03 | New England RevolutionvNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2022-04-02 | Toronto FCvNew York CityMLS · United States | 2–1 | MLS · United States |
| 2022-04-02 | Chicago FirevFC DallasMLS · United States | 0–0 | MLS · United States |
| 2022-04-02 | FC CincinnativCF MontrealMLS · United States | 3–4 | MLS · United States |
| 2022-04-02 | Columbus CrewvNashville SCMLS · United States | 0–1 | MLS · United States |
| 2022-03-27 | Portland TimbersvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2022-03-26 | Sporting Kansas CityvReal Salt LakeMLS · United States | 1–0 | MLS · United States |
| 2022-03-26 | CharlottevFC CincinnatiMLS · United States | 2–0 | MLS · United States |
| 2022-03-21 | Los Angeles FCvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2022-03-20 | Minnesota UnitedvSan Jose EarthquakesMLS · United States | 1–0 | MLS · United States |
| 2022-03-20 | Real Salt LakevNashville SCMLS · United States | 2–1 | MLS · United States |
| 2022-03-20 | Houston DynamovColorado RapidsMLS · United States | 1–1 | MLS · United States |
| 2022-03-20 | Austin FCvSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2022-03-20 | FC DallasvPortland TimbersMLS · United States | 4–1 | MLS · United States |
| 2022-03-20 | New York Red BullsvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2022-03-19 | Toronto FCvDC UnitedMLS · United States | 2–1 | MLS · United States |
| 2022-03-19 | Los Angeles GalaxyvOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2022-03-19 | New York CityvPhiladelphia UnionMLS · United States | 0–2 | MLS · United States |
| 2022-03-19 | FC CincinnativInter MiamiMLS · United States | 3–1 | MLS · United States |
| 2022-03-19 | Chicago FirevSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2022-03-19 | Atlanta UtdvCF MontrealMLS · United States | 3–3 | MLS · United States |
| 2022-03-19 | CharlottevNew England RevolutionMLS · United States | 3–1 | MLS · United States |
| 2022-03-13 | Orlando CityvFC CincinnatiMLS · United States | 1–2 | MLS · United States |
| 2022-03-13 | Philadelphia UnionvSan Jose EarthquakesMLS · United States | 2–0 | MLS · United States |