| 2022-05-08 | Los Angeles FCvPhiladelphia UnionMLS · United States | 2–2 | MLS · United States |
| 2022-05-08 | Minnesota UnitedvFC CincinnatiMLS · United States | 0–1 | MLS · United States |
| 2022-05-08 | San Jose EarthquakesvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2022-05-08 | New York Red BullsvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2022-05-08 | Vancouver WhitecapsvToronto FCMLS · United States | 1–0 | MLS · United States |
| 2022-05-08 | New England RevolutionvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2022-05-08 | New York CityvSporting Kansas CityMLS · United States | 0–0 | MLS · United States |
| 2022-05-08 | Nashville SCvReal Salt LakeMLS · United States | 2–0 | MLS · United States |
| 2022-05-08 | FC DallasvSeattle SoundersMLS · United States | 2–0 | MLS · United States |
| 2022-05-08 | DC UnitedvHouston DynamoMLS · United States | 2–0 | MLS · United States |
| 2022-05-07 | Atlanta UtdvChicago FireMLS · United States | 4–1 | MLS · United States |
| 2022-05-07 | CF MontrealvOrlando CityMLS · United States | 4–1 | MLS · United States |
| 2022-05-07 | CharlottevInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-05-05 | FC CincinnativToronto FCMLS · United States | 2–0 | MLS · United States |
| 2022-05-02 | Los Angeles FCvMinnesota UnitedMLS · United States | 2–0 | MLS · United States |
| 2022-05-01 | Orlando CityvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-05-01 | Nashville SCvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2022-05-01 | New England RevolutionvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2022-05-01 | New York CityvSan Jose EarthquakesMLS · United States | 3–0 | MLS · United States |
| 2022-05-01 | Columbus CrewvDC UnitedMLS · United States | 3–0 | MLS · United States |
| 2022-05-01 | Colorado RapidsvPortland TimbersMLS · United States | 2–0 | MLS · United States |
| 2022-05-01 | Chicago FirevNew York Red BullsMLS · United States | 1–2 | MLS · United States |
| 2022-05-01 | Sporting Kansas CityvFC DallasMLS · United States | 2–2 | MLS · United States |
| 2022-04-30 | Real Salt LakevLos Angeles GalaxyMLS · United States | 1–0 | MLS · United States |
| 2022-04-30 | Houston DynamovAustin FCMLS · United States | 1–2 | MLS · United States |
| 2022-04-30 | CF MontrealvAtlanta UtdMLS · United States | 2–1 | MLS · United States |
| 2022-04-30 | Toronto FCvFC CincinnatiMLS · United States | 1–2 | MLS · United States |
| 2022-04-24 | Orlando CityvNew York Red BullsMLS · United States | 0–3 | MLS · United States |
| 2022-04-24 | Sporting Kansas CityvColumbus CrewMLS · United States | 0–0 | MLS · United States |
| 2022-04-24 | Austin FCvVancouver WhitecapsMLS · United States | 3–0 | MLS · United States |
| 2022-04-24 | DC UnitedvNew England RevolutionMLS · United States | 3–2 | MLS · United States |
| 2022-04-24 | Inter MiamivAtlanta UtdMLS · United States | 2–1 | MLS · United States |
| 2022-04-24 | Portland TimbersvReal Salt LakeMLS · United States | 0–0 | MLS · United States |
| 2022-04-24 | Colorado RapidsvCharlotteMLS · United States | 0–0 | MLS · United States |
| 2022-04-24 | San Jose EarthquakesvSeattle SoundersMLS · United States | 4–3 | MLS · United States |
| 2022-04-24 | New York CityvToronto FCMLS · United States | 5–4 | MLS · United States |
| 2022-04-24 | FC CincinnativLos Angeles FCMLS · United States | 1–2 | MLS · United States |
| 2022-04-24 | Los Angeles GalaxyvNashville SCMLS · United States | 1–0 | MLS · United States |
| 2022-04-23 | FC DallasvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-04-23 | Minnesota UnitedvChicago FireMLS · United States | 3–0 | MLS · United States |
| 2022-04-23 | Philadelphia UnionvCF MontrealMLS · United States | 1–1 | MLS · United States |
| 2022-04-17 | DC UnitedvAustin FCMLS · United States | 2–3 | MLS · United States |
| 2022-04-17 | Los Angeles FCvSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2022-04-17 | Chicago FirevLos Angeles GalaxyMLS · United States | 0–0 | MLS · United States |
| 2022-04-17 | Seattle SoundersvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-04-17 | Minnesota UnitedvColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2022-04-17 | New York CityvReal Salt LakeMLS · United States | 6–0 | MLS · United States |
| 2022-04-17 | Columbus CrewvOrlando CityMLS · United States | 0–2 | MLS · United States |
| 2022-04-17 | New England RevolutionvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-04-17 | Toronto FCvPhiladelphia UnionMLS · United States | 2–1 | MLS · United States |