| 2022-08-14 | New England RevolutionvDC UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-08-14 | FC CincinnativAtlanta UtdMLS · United States | 2–2 | MLS · United States |
| 2022-08-14 | Austin FCvSporting Kansas CityMLS · United States | 4–3 | MLS · United States |
| 2022-08-14 | Los Angeles FCvCharlotteMLS · United States | 5–0 | MLS · United States |
| 2022-08-13 | New York Red BullsvOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2022-08-07 | Portland TimbersvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2022-08-07 | Columbus CrewvNew York CityMLS · United States | 3–2 | MLS · United States |
| 2022-08-07 | DC UnitedvNew York Red BullsMLS · United States | 0–0 | MLS · United States |
| 2022-08-07 | Nashville SCvToronto FCMLS · United States | 3–4 | MLS · United States |
| 2022-08-07 | Austin FCvSan Jose EarthquakesMLS · United States | 3–3 | MLS · United States |
| 2022-08-07 | Real Salt LakevLos Angeles FCMLS · United States | 1–4 | MLS · United States |
| 2022-08-07 | CharlottevChicago FireMLS · United States | 2–3 | MLS · United States |
| 2022-08-07 | Colorado RapidsvMinnesota UnitedMLS · United States | 4–3 | MLS · United States |
| 2022-08-07 | FC CincinnativPhiladelphia UnionMLS · United States | 3–1 | MLS · United States |
| 2022-08-07 | CF MontrealvInter MiamiMLS · United States | 2–2 | MLS · United States |
| 2022-08-07 | Orlando CityvNew England RevolutionMLS · United States | 0–3 | MLS · United States |
| 2022-08-07 | Sporting Kansas CityvLos Angeles GalaxyMLS · United States | 4–2 | MLS · United States |
| 2022-08-06 | Atlanta UtdvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-08-06 | Vancouver WhitecapsvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-08-04 | Columbus CrewvCF MontrealMLS · United States | 1–2 | MLS · United States |
| 2022-08-04 | CharlottevDC UnitedMLS · United States | 3–0 | MLS · United States |
| 2022-08-04 | Portland TimbersvNashville SCMLS · United States | 1–1 | MLS · United States |
| 2022-08-04 | San Jose EarthquakesvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-08-03 | New York Red BullsvColorado RapidsMLS · United States | 4–5 | MLS · United States |
| 2022-08-03 | Seattle SoundersvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2022-07-31 | New England RevolutionvToronto FCMLS · United States | 0–0 | MLS · United States |
| 2022-07-31 | Philadelphia UnionvHouston DynamoMLS · United States | 6–0 | MLS · United States |
| 2022-07-31 | Nashville SCvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2022-07-31 | Inter MiamivFC CincinnatiMLS · United States | 4–4 | MLS · United States |
| 2022-07-31 | FC DallasvLos Angeles GalaxyMLS · United States | 1–0 | MLS · United States |
| 2022-07-31 | CF MontrealvNew York CityMLS · United States | 0–0 | MLS · United States |
| 2022-07-31 | DC UnitedvOrlando CityMLS · United States | 2–1 | MLS · United States |
| 2022-07-31 | Sporting Kansas CityvAustin FCMLS · United States | 0–2 | MLS · United States |
| 2022-07-31 | San Jose EarthquakesvReal Salt LakeMLS · United States | 2–2 | MLS · United States |
| 2022-07-30 | Minnesota UnitedvPortland TimbersMLS · United States | 4–4 | MLS · United States |
| 2022-07-30 | Chicago FirevAtlanta UtdMLS · United States | 0–0 | MLS · United States |
| 2022-07-30 | Los Angeles FCvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-07-25 | Austin FCvNew York Red BullsMLS · United States | 3–4 | MLS · United States |
| 2022-07-25 | Los Angeles GalaxyvAtlanta UtdMLS · United States | 2–0 | MLS · United States |
| 2022-07-24 | Orlando CityvPhiladelphia UnionMLS · United States | 0–1 | MLS · United States |
| 2022-07-24 | Real Salt LakevFC DallasMLS · United States | 0–1 | MLS · United States |
| 2022-07-24 | Toronto FCvCharlotteMLS · United States | 4–0 | MLS · United States |
| 2022-07-24 | New York CityvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2022-07-24 | FC CincinnativNashville SCMLS · United States | 1–1 | MLS · United States |
| 2022-07-24 | Houston DynamovMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2022-07-24 | DC UnitedvCF MontrealMLS · United States | 1–2 | MLS · United States |
| 2022-07-24 | Portland TimbersvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2022-07-24 | Columbus CrewvNew England RevolutionMLS · United States | 0–0 | MLS · United States |
| 2022-07-24 | Seattle SoundersvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2022-07-24 | Sporting Kansas CityvLos Angeles FCMLS · United States | 0–2 | MLS · United States |