| 2022-07-01 | CharlottevAustin FCMLS · United States | 0–1 | MLS · United States |
| 2022-06-26 | CF MontrealvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-06-19 | Columbus CrewvCharlotteMLS · United States | 1–1 | MLS · United States |
| 2022-06-11 | CharlottevNew York Red BullsMLS · United States | 2–0 | MLS · United States |
| 2022-05-30 | Seattle SoundersvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-05-22 | CharlottevVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-05-15 | CharlottevCF MontrealMLS · United States | 0–2 | MLS · United States |
| 2022-05-07 | CharlottevInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-05-01 | Orlando CityvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-04-24 | Colorado RapidsvCharlotteMLS · United States | 0–0 | MLS · United States |
| 2022-04-17 | New England RevolutionvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-04-10 | CharlottevAtlanta UtdMLS · United States | 1–0 | MLS · United States |
| 2022-04-03 | Philadelphia UnionvCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-03-26 | CharlottevFC CincinnatiMLS · United States | 2–0 | MLS · United States |
| 2022-03-19 | CharlottevNew England RevolutionMLS · United States | 3–1 | MLS · United States |
| 2022-03-13 | Atlanta UtdvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-03-06 | CharlottevLos Angeles GalaxyMLS · United States | 0–1 | MLS · United States |
| 2022-02-26 | DC UnitedvCharlotteMLS · United States | 3–0 | MLS · United States |