| 2022-09-18 | Chicago FirevCharlotteMLS · United States | 2–3 | MLS · United States |
| 2022-09-18 | Real Salt LakevFC CincinnatiMLS · United States | 1–2 | MLS · United States |
| 2022-09-18 | Vancouver WhitecapsvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-09-18 | Sporting Kansas CityvMinnesota UnitedMLS · United States | 4–1 | MLS · United States |
| 2022-09-18 | Columbus CrewvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2022-09-18 | San Jose EarthquakesvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2022-09-18 | Austin FCvNashville SCMLS · United States | 1–1 | MLS · United States |
| 2022-09-18 | New England RevolutionvCF MontrealMLS · United States | 0–1 | MLS · United States |
| 2022-09-17 | New York CityvNew York Red BullsMLS · United States | 2–0 | MLS · United States |
| 2022-09-17 | Atlanta UtdvPhiladelphia UnionMLS · United States | 0–0 | MLS · United States |
| 2022-09-15 | Austin FCvReal Salt LakeMLS · United States | 3–0 | MLS · United States |
| 2022-09-15 | Vancouver WhitecapsvLos Angeles GalaxyMLS · United States | 3–0 | MLS · United States |
| 2022-09-15 | Colorado RapidsvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2022-09-14 | Orlando CityvAtlanta UtdMLS · United States | 0–1 | MLS · United States |
| 2022-09-14 | Minnesota UnitedvLos Angeles FCMLS · United States | 1–1 | MLS · United States |
| 2022-09-14 | Houston DynamovNew England RevolutionMLS · United States | 3–1 | MLS · United States |
| 2022-09-14 | Inter MiamivColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2022-09-14 | CF MontrealvChicago FireMLS · United States | 3–2 | MLS · United States |
| 2022-09-14 | Sporting Kansas CityvDC UnitedMLS · United States | 3–0 | MLS · United States |
| 2022-09-11 | FC DallasvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-09-11 | Philadelphia UnionvOrlando CityMLS · United States | 5–1 | MLS · United States |
| 2022-09-11 | Chicago FirevInter MiamiMLS · United States | 3–1 | MLS · United States |
| 2022-09-11 | Colorado RapidsvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2022-09-11 | FC CincinnativSan Jose EarthquakesMLS · United States | 6–0 | MLS · United States |
| 2022-09-11 | Real Salt LakevDC UnitedMLS · United States | 0–0 | MLS · United States |
| 2022-09-11 | Houston DynamovSporting Kansas CityMLS · United States | 0–0 | MLS · United States |
| 2022-09-11 | Seattle SoundersvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2022-09-11 | Portland TimbersvMinnesota UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-09-11 | Atlanta UtdvToronto FCMLS · United States | 4–2 | MLS · United States |
| 2022-09-10 | CF MontrealvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2022-09-10 | CharlottevNew York CityMLS · United States | 1–0 | MLS · United States |
| 2022-09-10 | Nashville SCvLos Angeles GalaxyMLS · United States | 1–1 | MLS · United States |
| 2022-09-10 | New York Red BullsvNew England RevolutionMLS · United States | 2–1 | MLS · United States |
| 2022-09-08 | New York CityvFC CincinnatiMLS · United States | 1–1 | MLS · United States |
| 2022-09-05 | Toronto FCvCF MontrealMLS · United States | 3–4 | MLS · United States |
| 2022-09-05 | Seattle SoundersvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-09-05 | DC UnitedvColorado RapidsMLS · United States | 0–0 | MLS · United States |
| 2022-09-05 | New England RevolutionvNew York CityMLS · United States | 3–0 | MLS · United States |
| 2022-09-05 | Los Angeles FCvReal Salt LakeMLS · United States | 2–0 | MLS · United States |
| 2022-09-05 | Los Angeles GalaxyvSporting Kansas CityMLS · United States | 2–2 | MLS · United States |
| 2022-09-05 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 2–0 | MLS · United States |
| 2022-09-04 | Nashville SCvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2022-09-04 | Portland TimbersvAtlanta UtdMLS · United States | 2–1 | MLS · United States |
| 2022-09-04 | FC CincinnativCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-09-04 | New York Red BullsvPhiladelphia UnionMLS · United States | 0–2 | MLS · United States |
| 2022-09-03 | Columbus CrewvChicago FireMLS · United States | 0–0 | MLS · United States |
| 2022-09-03 | Minnesota UnitedvFC DallasMLS · United States | 0–3 | MLS · United States |
| 2022-09-01 | Toronto FCvLos Angeles GalaxyMLS · United States | 2–2 | MLS · United States |
| 2022-09-01 | Austin FCvPortland TimbersMLS · United States | 1–2 | MLS · United States |
| 2022-09-01 | New York CityvDC UnitedMLS · United States | 1–2 | MLS · United States |