| 2022-09-01 | Philadelphia UnionvAtlanta UtdMLS · United States | 4–1 | MLS · United States |
| 2022-09-01 | CF MontrealvNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2022-09-01 | Real Salt LakevMinnesota UnitedMLS · United States | 3–0 | MLS · United States |
| 2022-09-01 | Columbus CrewvInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-09-01 | Nashville SCvColorado RapidsMLS · United States | 4–1 | MLS · United States |
| 2022-09-01 | Orlando CityvSeattle SoundersMLS · United States | 3–2 | MLS · United States |
| 2022-09-01 | New England RevolutionvChicago FireMLS · United States | 0–0 | MLS · United States |
| 2022-08-29 | New England RevolutionvLos Angeles GalaxyMLS · United States | 1–2 | MLS · United States |
| 2022-08-29 | Orlando CityvNew York CityMLS · United States | 2–1 | MLS · United States |
| 2022-08-28 | FC CincinnativColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2022-08-28 | Philadelphia UnionvColorado RapidsMLS · United States | 6–0 | MLS · United States |
| 2022-08-28 | FC DallasvReal Salt LakeMLS · United States | 1–1 | MLS · United States |
| 2022-08-28 | Vancouver WhitecapsvNashville SCMLS · United States | 0–3 | MLS · United States |
| 2022-08-28 | New York Red BullsvInter MiamiMLS · United States | 3–1 | MLS · United States |
| 2022-08-28 | Chicago FirevCF MontrealMLS · United States | 0–2 | MLS · United States |
| 2022-08-28 | Sporting Kansas CityvSan Jose EarthquakesMLS · United States | 1–0 | MLS · United States |
| 2022-08-28 | CharlottevToronto FCMLS · United States | 0–2 | MLS · United States |
| 2022-08-28 | Atlanta UtdvDC UnitedMLS · United States | 3–2 | MLS · United States |
| 2022-08-27 | Austin FCvLos Angeles FCMLS · United States | 4–1 | MLS · United States |
| 2022-08-27 | Portland TimbersvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-08-27 | Minnesota UnitedvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-08-22 | Nashville SCvFC DallasMLS · United States | 4–0 | MLS · United States |
| 2022-08-22 | Sporting Kansas CityvPortland TimbersMLS · United States | 4–1 | MLS · United States |
| 2022-08-22 | CharlottevOrlando CityMLS · United States | 1–2 | MLS · United States |
| 2022-08-21 | Minnesota UnitedvAustin FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-21 | CF MontrealvNew England RevolutionMLS · United States | 4–0 | MLS · United States |
| 2022-08-21 | Chicago FirevNew York CityMLS · United States | 0–2 | MLS · United States |
| 2022-08-21 | Columbus CrewvAtlanta UtdMLS · United States | 2–2 | MLS · United States |
| 2022-08-21 | Real Salt LakevVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2022-08-21 | Colorado RapidsvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2022-08-21 | Inter MiamivToronto FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-21 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-21 | DC UnitedvPhiladelphia UnionMLS · United States | 0–6 | MLS · United States |
| 2022-08-20 | Los Angeles GalaxyvSeattle SoundersMLS · United States | 3–3 | MLS · United States |
| 2022-08-20 | New York Red BullsvFC CincinnatiMLS · United States | 1–1 | MLS · United States |
| 2022-08-18 | New York CityvCharlotteMLS · United States | 1–3 | MLS · United States |
| 2022-08-18 | Toronto FCvNew England RevolutionMLS · United States | 2–2 | MLS · United States |
| 2022-08-18 | FC DallasvPhiladelphia UnionMLS · United States | 1–0 | MLS · United States |
| 2022-08-18 | Atlanta UtdvNew York Red BullsMLS · United States | 1–2 | MLS · United States |
| 2022-08-18 | Vancouver WhitecapsvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2022-08-17 | Los Angeles FCvDC UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-08-15 | Nashville SCvMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2022-08-15 | Seattle SoundersvReal Salt LakeMLS · United States | 1–2 | MLS · United States |
| 2022-08-14 | Philadelphia UnionvChicago FireMLS · United States | 4–1 | MLS · United States |
| 2022-08-14 | Colorado RapidsvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2022-08-14 | Los Angeles GalaxyvVancouver WhitecapsMLS · United States | 5–2 | MLS · United States |
| 2022-08-14 | Houston DynamovCF MontrealMLS · United States | 2–3 | MLS · United States |
| 2022-08-14 | Inter MiamivNew York CityMLS · United States | 3–2 | MLS · United States |
| 2022-08-14 | FC DallasvSan Jose EarthquakesMLS · United States | 4–1 | MLS · United States |
| 2022-08-14 | Toronto FCvPortland TimbersMLS · United States | 3–1 | MLS · United States |