| 2023-06-22 | St. Louis CityvReal Salt LakeMLS · United States | 1–3 | MLS · United States |
| 2023-06-18 | Nashville SCvSt. Louis CityMLS · United States | 3–1 | MLS · United States |
| 2023-06-11 | St. Louis CityvLos Angeles GalaxyMLS · United States | 1–1 | MLS · United States |
| 2023-06-08 | FC DallasvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2023-06-04 | St. Louis CityvHouston DynamoMLS · United States | 3–0 | MLS · United States |
| 2023-05-28 | St. Louis CityvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2023-05-21 | St. Louis CityvSporting Kansas CityMLS · United States | 4–0 | MLS · United States |
| 2023-05-13 | Chicago FirevSt. Louis CityMLS · United States | 1–0 | MLS · United States |
| 2023-04-30 | St. Louis CityvPortland TimbersMLS · United States | 1–2 | MLS · United States |
| 2023-04-23 | Colorado RapidsvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2023-04-16 | St. Louis CityvFC CincinnatiMLS · United States | 5–1 | MLS · United States |
| 2023-04-09 | Seattle SoundersvSt. Louis CityMLS · United States | 3–0 | MLS · United States |
| 2023-04-02 | St. Louis CityvMinnesota UnitedMLS · United States | 0–1 | MLS · United States |
| 2023-03-26 | Real Salt LakevSt. Louis CityMLS · United States | 0–4 | MLS · United States |
| 2023-03-19 | St. Louis CityvSan Jose EarthquakesMLS · United States | 3–0 | MLS · United States |
| 2023-03-12 | Portland TimbersvSt. Louis CityMLS · United States | 1–2 | MLS · United States |
| 2023-03-05 | St. Louis CityvCharlotteMLS · United States | 3–1 | MLS · United States |
| 2023-02-26 | Austin FCvSt. Louis CityMLS · United States | 2–3 | MLS · United States |