| 2012-05-06 | Los Angeles GalaxyvNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2012-05-06 | Sporting Kansas CityvCF MontrealMLS · United States | 0–2 | MLS · United States |
| 2012-05-06 | Real Salt LakevNew England RevolutionMLS · United States | 2–1 | MLS · United States |
| 2012-05-06 | Vancouver WhitecapsvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2012-05-06 | Portland TimbersvColumbus CrewMLS · United States | 0–0 | MLS · United States |
| 2012-05-05 | Toronto FCvDC UnitedMLS · United States | 0–2 | MLS · United States |
| 2012-05-05 | Seattle SoundersvPhiladelphia UnionMLS · United States | 1–0 | MLS · United States |
| 2012-05-05 | Chivas USAvChicago FireMLS · United States | 1–2 | MLS · United States |
| 2012-05-03 | Seattle SoundersvLos Angeles GalaxyMLS · United States | 2–0 | MLS · United States |
| 2012-05-03 | San Jose EarthquakesvDC UnitedMLS · United States | 5–3 | MLS · United States |
| 2012-05-03 | New England RevolutionvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2012-04-29 | Real Salt LakevToronto FCMLS · United States | 3–2 | MLS · United States |
| 2012-04-29 | Philadelphia UnionvSan Jose EarthquakesMLS · United States | 1–2 | MLS · United States |
| 2012-04-29 | Los Angeles GalaxyvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2012-04-29 | DC UnitedvHouston DynamoMLS · United States | 3–2 | MLS · United States |
| 2012-04-29 | Chicago FirevSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2012-04-29 | Columbus CrewvVancouver WhitecapsMLS · United States | 0–1 | MLS · United States |
| 2012-04-29 | Colorado RapidsvChivas USAMLS · United States | 4–0 | MLS · United States |
| 2012-04-28 | CF MontrealvPortland TimbersMLS · United States | 2–0 | MLS · United States |
| 2012-04-28 | New York Red BullsvNew England RevolutionMLS · United States | 1–0 | MLS · United States |
| 2012-04-26 | FC DallasvReal Salt LakeMLS · United States | 1–1 | MLS · United States |
| 2012-04-22 | Chivas USAvPhiladelphia UnionMLS · United States | 0–1 | MLS · United States |
| 2012-04-22 | San Jose EarthquakesvReal Salt LakeMLS · United States | 3–1 | MLS · United States |
| 2012-04-22 | Portland TimbersvSporting Kansas CityMLS · United States | 1–0 | MLS · United States |
| 2012-04-22 | Columbus CrewvHouston DynamoMLS · United States | 2–2 | MLS · United States |
| 2012-04-22 | DC UnitedvNew York Red BullsMLS · United States | 4–1 | MLS · United States |
| 2012-04-22 | Vancouver WhitecapsvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2012-04-22 | Colorado RapidsvLos Angeles GalaxyMLS · United States | 1–2 | MLS · United States |
| 2012-04-21 | Toronto FCvChicago FireMLS · United States | 2–3 | MLS · United States |
| 2012-04-19 | DC UnitedvCF MontrealMLS · United States | 1–1 | MLS · United States |
| 2012-04-19 | Vancouver WhitecapsvSporting Kansas CityMLS · United States | 1–3 | MLS · United States |
| 2012-04-16 | Chicago FirevHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2012-04-15 | FC DallasvCF MontrealMLS · United States | 2–1 | MLS · United States |
| 2012-04-15 | New York Red BullsvSan Jose EarthquakesMLS · United States | 2–2 | MLS · United States |
| 2012-04-15 | Los Angeles GalaxyvPortland TimbersMLS · United States | 3–1 | MLS · United States |
| 2012-04-15 | Sporting Kansas CityvReal Salt LakeMLS · United States | 1–0 | MLS · United States |
| 2012-04-14 | Seattle SoundersvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2012-04-14 | Toronto FCvChivas USAMLS · United States | 0–1 | MLS · United States |
| 2012-04-14 | Philadelphia UnionvColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2012-04-14 | New England RevolutionvDC UnitedMLS · United States | 1–2 | MLS · United States |
| 2012-04-08 | Portland TimbersvChivas USAMLS · United States | 1–2 | MLS · United States |
| 2012-04-08 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2012-04-08 | DC UnitedvSeattle SoundersMLS · United States | 0–0 | MLS · United States |
| 2012-04-08 | Real Salt LakevColorado RapidsMLS · United States | 2–0 | MLS · United States |
| 2012-04-07 | Columbus CrewvNew York Red BullsMLS · United States | 1–4 | MLS · United States |
| 2012-04-07 | CF MontrealvToronto FCMLS · United States | 2–1 | MLS · United States |
| 2012-04-07 | Sporting Kansas CityvLos Angeles GalaxyMLS · United States | 1–0 | MLS · United States |
| 2012-04-06 | FC DallasvNew England RevolutionMLS · United States | 1–0 | MLS · United States |
| 2012-04-05 | Real Salt LakevCF MontrealMLS · United States | 1–0 | MLS · United States |
| 2012-04-02 | Chivas USAvSporting Kansas CityMLS · United States | 0–1 | MLS · United States |