| 2012-09-29 | Sporting Kansas CityvChicago FireMLS · United States | 2–0 | MLS · United States |
| 2012-09-24 | Vancouver WhitecapsvColorado RapidsMLS · United States | 2–2 | MLS · United States |
| 2012-09-24 | DC UnitedvChivas USAMLS · United States | 1–0 | MLS · United States |
| 2012-09-23 | New England RevolutionvNew York Red BullsMLS · United States | 1–1 | MLS · United States |
| 2012-09-23 | Seattle SoundersvSan Jose EarthquakesMLS · United States | 1–2 | MLS · United States |
| 2012-09-23 | Philadelphia UnionvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2012-09-23 | Real Salt LakevPortland TimbersMLS · United States | 2–1 | MLS · United States |
| 2012-09-23 | Los Angeles GalaxyvToronto FCMLS · United States | 4–2 | MLS · United States |
| 2012-09-23 | Chicago FirevColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2012-09-22 | CF MontrealvSporting Kansas CityMLS · United States | 0–0 | MLS · United States |
| 2012-09-21 | Philadelphia UnionvDC UnitedMLS · United States | 0–1 | MLS · United States |
| 2012-09-20 | New York Red BullsvSporting Kansas CityMLS · United States | 0–2 | MLS · United States |
| 2012-09-20 | San Jose EarthquakesvPortland TimbersMLS · United States | 2–2 | MLS · United States |
| 2012-09-20 | Columbus CrewvChivas USAMLS · United States | 1–0 | MLS · United States |
| 2012-09-16 | FC DallasvVancouver WhitecapsMLS · United States | 1–0 | MLS · United States |
| 2012-09-16 | Chivas USAvSan Jose EarthquakesMLS · United States | 0–2 | MLS · United States |
| 2012-09-16 | New York Red BullsvColumbus CrewMLS · United States | 3–1 | MLS · United States |
| 2012-09-16 | DC UnitedvNew England RevolutionMLS · United States | 2–1 | MLS · United States |
| 2012-09-16 | Chicago FirevCF MontrealMLS · United States | 3–1 | MLS · United States |
| 2012-09-15 | Los Angeles GalaxyvColorado RapidsMLS · United States | 2–0 | MLS · United States |
| 2012-09-15 | Sporting Kansas CityvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2012-09-15 | Portland TimbersvSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2012-09-15 | Toronto FCvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2012-09-13 | Toronto FCvChicago FireMLS · United States | 1–2 | MLS · United States |
| 2012-09-08 | Seattle SoundersvChivas USAMLS · United States | 2–1 | MLS · United States |
| 2012-09-07 | Houston DynamovReal Salt LakeMLS · United States | 1–0 | MLS · United States |
| 2012-09-06 | Colorado RapidsvPortland TimbersMLS · United States | 3–0 | MLS · United States |
| 2012-09-06 | New England RevolutionvColumbus CrewMLS · United States | 2–0 | MLS · United States |
| 2012-09-03 | Chicago FirevHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2012-09-03 | San Jose EarthquakesvChivas USAMLS · United States | 4–0 | MLS · United States |
| 2012-09-03 | FC DallasvSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2012-09-02 | Real Salt LakevDC UnitedMLS · United States | 1–0 | MLS · United States |
| 2012-09-02 | Sporting Kansas CityvToronto FCMLS · United States | 2–1 | MLS · United States |
| 2012-09-02 | Columbus CrewvCF MontrealMLS · United States | 2–1 | MLS · United States |
| 2012-09-02 | Los Angeles GalaxyvVancouver WhitecapsMLS · United States | 2–0 | MLS · United States |
| 2012-09-02 | New England RevolutionvPhiladelphia UnionMLS · United States | 0–0 | MLS · United States |
| 2012-09-01 | Portland TimbersvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2012-08-30 | Philadelphia UnionvColumbus CrewMLS · United States | 1–2 | MLS · United States |
| 2012-08-30 | DC UnitedvNew York Red BullsMLS · United States | 2–2 | MLS · United States |
| 2012-08-30 | New England RevolutionvChivas USAMLS · United States | 3–3 | MLS · United States |
| 2012-08-27 | Los Angeles GalaxyvFC DallasMLS · United States | 2–0 | MLS · United States |
| 2012-08-27 | Sporting Kansas CityvNew York Red BullsMLS · United States | 1–1 | MLS · United States |
| 2012-08-26 | Houston DynamovToronto FCMLS · United States | 1–1 | MLS · United States |
| 2012-08-26 | San Jose EarthquakesvColorado RapidsMLS · United States | 4–1 | MLS · United States |
| 2012-08-26 | Portland TimbersvVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2012-08-26 | Columbus CrewvNew England RevolutionMLS · United States | 4–3 | MLS · United States |
| 2012-08-26 | Chivas USAvSeattle SoundersMLS · United States | 2–6 | MLS · United States |
| 2012-08-25 | Philadelphia UnionvReal Salt LakeMLS · United States | 0–0 | MLS · United States |
| 2012-08-25 | CF MontrealvDC UnitedMLS · United States | 3–0 | MLS · United States |
| 2012-08-23 | Columbus CrewvToronto FCMLS · United States | 2–1 | MLS · United States |