| 2022-03-13 | Portland TimbersvAustin FCMLS · United States | 1–0 | MLS · United States |
| 2022-03-13 | New York Red BullsvMinnesota UnitedMLS · United States | 0–1 | MLS · United States |
| 2022-03-13 | New England RevolutionvReal Salt LakeMLS · United States | 2–3 | MLS · United States |
| 2022-03-13 | Colorado RapidsvSporting Kansas CityMLS · United States | 2–0 | MLS · United States |
| 2022-03-13 | FC DallasvNashville SCMLS · United States | 2–0 | MLS · United States |
| 2022-03-13 | Atlanta UtdvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-03-12 | Columbus CrewvToronto FCMLS · United States | 2–1 | MLS · United States |
| 2022-03-12 | Inter MiamivLos Angeles FCMLS · United States | 0–2 | MLS · United States |
| 2022-03-12 | New York CityvCF MontrealMLS · United States | 4–1 | MLS · United States |
| 2022-03-12 | Seattle SoundersvLos Angeles GalaxyMLS · United States | 3–2 | MLS · United States |
| 2022-03-12 | Houston DynamovVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-03-07 | Los Angeles FCvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2022-03-06 | CharlottevLos Angeles GalaxyMLS · United States | 0–1 | MLS · United States |
| 2022-03-06 | Austin FCvInter MiamiMLS · United States | 5–1 | MLS · United States |
| 2022-03-05 | Vancouver WhitecapsvNew York CityMLS · United States | 0–0 | MLS · United States |
| 2022-03-05 | Chicago FirevOrlando CityMLS · United States | 0–0 | MLS · United States |
| 2022-03-05 | Real Salt LakevSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-03-05 | Minnesota UnitedvNashville SCMLS · United States | 1–1 | MLS · United States |
| 2022-03-05 | New England RevolutionvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2022-03-05 | Sporting Kansas CityvHouston DynamoMLS · United States | 1–0 | MLS · United States |
| 2022-03-05 | Colorado RapidsvAtlanta UtdMLS · United States | 3–0 | MLS · United States |
| 2022-03-05 | San Jose EarthquakesvColumbus CrewMLS · United States | 3–3 | MLS · United States |
| 2022-03-05 | Toronto FCvNew York Red BullsMLS · United States | 1–4 | MLS · United States |
| 2022-03-05 | CF MontrealvPhiladelphia UnionMLS · United States | 1–2 | MLS · United States |
| 2022-03-05 | FC CincinnativDC UnitedMLS · United States | 0–1 | MLS · United States |
| 2022-02-28 | Houston DynamovReal Salt LakeMLS · United States | 0–0 | MLS · United States |
| 2022-02-28 | Seattle SoundersvNashville SCMLS · United States | 0–1 | MLS · United States |
| 2022-02-27 | Orlando CityvCF MontrealMLS · United States | 2–0 | MLS · United States |
| 2022-02-27 | Los Angeles GalaxyvNew York CityMLS · United States | 1–0 | MLS · United States |
| 2022-02-27 | Portland TimbersvNew England RevolutionMLS · United States | 2–2 | MLS · United States |
| 2022-02-27 | Atlanta UtdvSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2022-02-26 | Inter MiamivChicago FireMLS · United States | 0–0 | MLS · United States |
| 2022-02-26 | Los Angeles FCvColorado RapidsMLS · United States | 3–0 | MLS · United States |
| 2022-02-26 | Austin FCvFC CincinnatiMLS · United States | 5–0 | MLS · United States |
| 2022-02-26 | San Jose EarthquakesvNew York Red BullsMLS · United States | 1–3 | MLS · United States |
| 2022-02-26 | Columbus CrewvVancouver WhitecapsMLS · United States | 4–0 | MLS · United States |
| 2022-02-26 | Philadelphia UnionvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |
| 2022-02-26 | DC UnitedvCharlotteMLS · United States | 3–0 | MLS · United States |
| 2022-02-26 | FC DallasvToronto FCMLS · United States | 1–1 | MLS · United States |