| 2021-11-07 | AlmeriavBurgosLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-11-06 | ValladolidvMirandesLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-11-06 | OviedovLas PalmasLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-11-06 | LugovPonferradinaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-11-06 | FuenlabradavEibarLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-11-05 | HuescavLeganesLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-11-04 | IbizavTenerifeLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-11-04 | BurgosvZaragozaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-11-04 | MalagavSociedad BLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-11-04 | GironavAlcorconLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-11-03 | MirandesvLugoLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2021-11-03 | Las PalmasvFuenlabradaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-11-03 | EibarvOviedoLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-11-03 | AmorebietavValladolidLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2021-11-02 | Sp GijonvAlmeriaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-11-02 | LeganesvCartagenaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-11-02 | PonferradinavHuescaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-11-01 | TenerifevBurgosLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2021-11-01 | AlcorconvIbizaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-10-31 | OviedovMalagaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-10-31 | ZaragozavMirandesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-31 | FuenlabradavGironaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-31 | ValladolidvEibarLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-10-30 | HuescavAmorebietaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-30 | CartagenavPonferradinaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-10-30 | LugovSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-29 | AlmeriavLeganesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-29 | Sociedad BvLas PalmasLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-10-25 | GironavZaragozaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-24 | BurgosvHuescaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-10-24 | PonferradinavOviedoLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-24 | Las PalmasvAlcorconLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-10-24 | MirandesvAlmeriaLa Liga 2 · Spain | 1–4 | La Liga 2 · Spain |
| 2021-10-24 | AmorebietavSociedad BLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-23 | MalagavLugoLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-23 | IbizavFuenlabradaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-10-23 | LeganesvTenerifeLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-23 | Sp GijonvValladolidLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-22 | EibarvCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-10-21 | AlmeriavSociedad BLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-10-21 | MirandesvGironaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-21 | ZaragozavPonferradinaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-21 | OviedovBurgosLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2021-10-20 | LugovLas PalmasLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-10-20 | ValladolidvIbizaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-20 | FuenlabradavAmorebietaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-10-20 | AlcorconvLeganesLa Liga 2 · Spain | 3–3 | La Liga 2 · Spain |
| 2021-10-19 | TenerifevEibarLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-10-19 | CartagenavSp GijonLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-19 | HuescavMalagaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |