| 2021-12-13 | SochivSpartak MoscowPremier League · Russia | 3–0 | Premier League · Russia |
| 2021-12-04 | Spartak MoscowvAkhmat GroznyPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-11-29 | UfavSpartak MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-11-20 | KrasnodarvSpartak MoscowPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-11-07 | Spartak MoscowvLokomotiv MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-10-30 | Spartak MoscowvFK RostovPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-10-24 | ZenitvSpartak MoscowPremier League · Russia | 7–1 | Premier League · Russia |
| 2021-10-16 | Spartak MoscowvDynamo MoscowPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-10-03 | Akhmat GroznyvSpartak MoscowPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-09-25 | Spartak MoscowvUfaPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-09-20 | CSKA MoscowvSpartak MoscowPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-09-11 | Spartak MoscowvKhimkiPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-08-26 | Spartak MoscowvSochiPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-08-21 | Arsenal TulavSpartak MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-14 | Spartak MoscowvUralPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-08-07 | Spartak MoscowvPari NNPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-07-30 | Krylya SovetovvSpartak MoscowPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-07-24 | Rubin KazanvSpartak MoscowPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-05-16 | Akhmat GroznyvSpartak MoscowPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-05-10 | Spartak MoscowvKhimkiPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-05-03 | Arsenal TulavSpartak MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-04-25 | Spartak MoscowvCSKA MoscowPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-04-18 | Spartak MoscowvUfaPremier League · Russia | 0–3 | Premier League · Russia |
| 2021-04-11 | Lokomotiv MoscowvSpartak MoscowPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-04-04 | FK RostovvSpartak MoscowPremier League · Russia | 2–3 | Premier League · Russia |
| 2021-03-18 | Spartak MoscowvUralPremier League · Russia | 5–1 | Premier League · Russia |
| 2021-03-13 | Dynamo MoscowvSpartak MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-03-07 | Spartak MoscowvKrasnodarPremier League · Russia | 6–1 | Premier League · Russia |
| 2021-02-28 | Spartak MoscowvRubin KazanPremier League · Russia | 0–2 | Premier League · Russia |