| 2021-11-28 | Club AmericavUNAM PumasLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2021-11-25 | UNAM PumasvClub AmericaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-11-07 | Club AmericavMonterreyLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-10-31 | Cruz AzulvClub AmericaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-10-24 | Club AmericavTigres UANLLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-10-20 | Club AmericavSantos LagunaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-10-17 | Atl. San LuisvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-10-03 | Club AmericavUNAM PumasLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-09-29 | PachucavClub AmericaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-09-26 | Club AmericavGuadalajara ChivasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-09-19 | TolucavClub AmericaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-09-12 | Club AmericavMazatlan FCLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-08-29 | Club LeonvClub AmericaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-22 | Club AmericavClub TijuanaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-08-19 | JuarezvClub AmericaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-08-15 | AtlasvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-08-08 | Club AmericavPueblaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-08-01 | Club AmericavNecaxaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-07-23 | QueretarovClub AmericaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-05-17 | Club AmericavPachucaLiga MX · Mexico | 4–2 | Liga MX · Mexico |
| 2021-05-14 | PachucavClub AmericaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-05-03 | UNAM PumasvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-04-25 | TolucavClub AmericaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-04-18 | Club AmericavCruz AzulLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-04-11 | Tigres UANLvClub AmericaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2021-04-04 | Club AmericavNecaxaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-03-20 | Mazatlan FCvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-03-15 | Guadalajara ChivasvClub AmericaLiga MX · Mexico | 0–3 | Liga MX · Mexico |
| 2021-03-07 | Club AmericavClub LeonLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-03-04 | Club TijuanavClub AmericaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-02-28 | Club AmericavPachucaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-02-21 | AtlasvClub AmericaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-02-14 | Club AmericavQueretaroLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-02-07 | Club AmericavPueblaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-02-01 | Santos LagunavClub AmericaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-01-27 | Club AmericavJuarezLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-01-17 | MonterreyvClub AmericaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-01-10 | Club AmericavAtl. San LuisLiga MX · Mexico | 2–1 | Liga MX · Mexico |