| 2022-12-28 | BrestvLyonLigue 1 · France | 2–4 | Ligue 1 · France |
| 2022-11-11 | LyonvNiceLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-11-06 | MarseillevLyonLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-10-30 | LyonvLilleLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-10-22 | MontpelliervLyonLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-10-16 | RennesvLyonLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-10-07 | LyonvToulouseLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-10-02 | LensvLyonLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-09-18 | LyonvParis SGLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-09-11 |  MonacovLyonLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-09-07 | LorientvLyonLigue 1 · France | 3–1 | Ligue 1 · France |
| 2022-09-03 | LyonvAngersLigue 1 · France | 5–0 | Ligue 1 · France |
| 2022-08-31 | LyonvAuxerreLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-08-28 | ReimsvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-08-19 | LyonvTroyesLigue 1 · France | 4–1 | Ligue 1 · France |
| 2022-08-05 | LyonvAjaccioLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-05-21 | ClermontvLyonLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-05-14 | LyonvNantesLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-05-08 | MetzvLyonLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-05-01 | MarseillevLyonLigue 1 · France | 0–3 | Ligue 1 · France |
| 2022-04-23 | LyonvMontpellierLigue 1 · France | 5–2 | Ligue 1 · France |
| 2022-04-20 | BrestvLyonLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-17 | LyonvBordeauxLigue 1 · France | 6–1 | Ligue 1 · France |
| 2022-04-10 | StrasbourgvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-04-03 | LyonvAngersLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-03-20 | ReimsvLyonLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-03-13 | LyonvRennesLigue 1 · France | 2–4 | Ligue 1 · France |
| 2022-03-04 | LorientvLyonLigue 1 · France | 1–4 | Ligue 1 · France |
| 2022-02-27 | LyonvLilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-19 | LensvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-02-12 | LyonvNiceLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-02-05 | MonacovLyonLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-02-01 | LyonvMarseilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-01-21 | LyonvSt EtienneLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-01-16 | TroyesvLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-01-09 | LyonvParis SGLigue 1 · France | 1–1 | Ligue 1 · France |