| 2022-05-15 | EastleighvGrimsbyNational League · England | 4–4 | National League · England |
| 2022-05-10 | GrimsbyvBoreham WoodNational League · England | 1–0 | National League · England |
| 2022-05-07 | GrimsbyvMaidenheadNational League · England | 1–3 | National League · England |
| 2022-04-30 | BarnetvGrimsbyNational League · England | 2–2 | National League · England |
| 2022-04-23 | GrimsbyvTorquayNational League · England | 2–1 | National League · England |
| 2022-04-18 | Kings LynnvGrimsbyNational League · England | 0–1 | National League · England |
| 2022-04-15 | GrimsbyvStockportNational League · England | 2–1 | National League · England |
| 2022-04-09 | WeymouthvGrimsbyNational League · England | 0–0 | National League · England |
| 2022-04-02 | ChesterfieldvGrimsbyNational League · England | 1–4 | National League · England |
| 2022-03-26 | GrimsbyvDag and RedNational League · England | 2–1 | National League · England |
| 2022-03-22 | GrimsbyvSolihullNational League · England | 1–2 | National League · England |
| 2022-03-19 | Boreham WoodvGrimsbyNational League · England | 0–0 | National League · England |
| 2022-03-12 | YeovilvGrimsbyNational League · England | 0–2 | National League · England |
| 2022-03-08 | SouthendvGrimsbyNational League · England | 1–0 | National League · England |
| 2022-03-05 | GrimsbyvWokingNational League · England | 1–0 | National League · England |
| 2022-02-26 | Dover AthleticvGrimsbyNational League · England | 1–3 | National League · England |
| 2022-02-12 | GrimsbyvAldershotNational League · England | 3–1 | National League · England |
| 2022-02-08 | GrimsbyvKings LynnNational League · England | 0–0 | National League · England |
| 2022-02-05 | Notts CountyvGrimsbyNational League · England | 1–2 | National League · England |
| 2022-01-29 | GrimsbyvWealdstoneNational League · England | 2–1 | National League · England |
| 2022-01-25 | WrexhamvGrimsbyNational League · England | 1–0 | National League · England |
| 2022-01-22 | GrimsbyvBromleyNational League · England | 1–2 | National League · England |
| 2022-01-15 | GrimsbyvAltrinchamNational League · England | 2–0 | National League · England |
| 2022-01-11 | HalifaxvGrimsbyNational League · England | 1–0 | National League · England |
| 2022-01-03 | GrimsbyvHalifaxNational League · England | 1–1 | National League · England |