| 2021-12-11 | GrimsbyvChesterfieldNational League · England | 0–1 | National League · England |
| 2021-12-04 | Dag and RedvGrimsbyNational League · England | 3–2 | National League · England |
| 2021-11-23 | SolihullvGrimsbyNational League · England | 2–0 | National League · England |
| 2021-11-19 | GrimsbyvSouthendNational League · England | 1–0 | National League · England |
| 2021-11-13 | AldershotvGrimsbyNational League · England | 2–1 | National League · England |
| 2021-10-30 | GrimsbyvNotts CountyNational League · England | 0–1 | National League · England |
| 2021-10-26 | WealdstonevGrimsbyNational League · England | 1–0 | National League · England |
| 2021-10-23 | GrimsbyvYeovilNational League · England | 2–0 | National League · England |
| 2021-10-09 | WokingvGrimsbyNational League · England | 0–1 | National League · England |
| 2021-10-05 | AltrinchamvGrimsbyNational League · England | 2–3 | National League · England |
| 2021-10-02 | GrimsbyvDover AthleticNational League · England | 6–0 | National League · England |
| 2021-09-28 | BromleyvGrimsbyNational League · England | 3–1 | National League · England |
| 2021-09-25 | MaidenheadvGrimsbyNational League · England | 1–1 | National League · England |
| 2021-09-18 | GrimsbyvEastleighNational League · England | 2–0 | National League · England |
| 2021-09-14 | GrimsbyvWrexhamNational League · England | 3–1 | National League · England |
| 2021-09-11 | TorquayvGrimsbyNational League · England | 1–3 | National League · England |
| 2021-09-04 | GrimsbyvBarnetNational League · England | 4–3 | National League · England |
| 2021-08-31 | StockportvGrimsbyNational League · England | 0–0 | National League · England |
| 2021-08-28 | GrimsbyvWeymouthNational League · England | 1–0 | National League · England |