| 2022-02-22 | EastleighvSouthendNational League · England | 1–1 | National League · England |
| 2022-02-12 | WokingvSouthendNational League · England | 2–3 | National League · England |
| 2022-02-08 | SouthendvBromleyNational League · England | 2–0 | National League · England |
| 2022-02-01 | SouthendvBarnetNational League · England | 2–1 | National League · England |
| 2022-01-29 | Dover AthleticvSouthendNational League · England | 0–1 | National League · England |
| 2022-01-25 | AldershotvSouthendNational League · England | 1–1 | National League · England |
| 2022-01-21 | SouthendvKings LynnNational League · England | 2–1 | National League · England |
| 2022-01-11 | SouthendvYeovilNational League · England | 2–1 | National League · England |
| 2022-01-08 | WeymouthvSouthendNational League · England | 0–1 | National League · England |
| 2021-12-26 | BromleyvSouthendNational League · England | 1–1 | National League · England |
| 2021-12-11 | Notts CountyvSouthendNational League · England | 4–1 | National League · England |
| 2021-12-07 | SouthendvMaidenheadNational League · England | 1–1 | National League · England |
| 2021-11-27 | AltrinchamvSouthendNational League · England | 1–2 | National League · England |
| 2021-11-19 | GrimsbyvSouthendNational League · England | 1–0 | National League · England |
| 2021-11-13 | SouthendvWokingNational League · England | 0–2 | National League · England |
| 2021-11-02 | SouthendvDover AthleticNational League · England | 4–1 | National League · England |
| 2021-10-30 | Boreham WoodvSouthendNational League · England | 1–0 | National League · England |
| 2021-10-23 | Dag and RedvSouthendNational League · England | 3–0 | National League · England |
| 2021-10-09 | SouthendvChesterfieldNational League · England | 0–4 | National League · England |
| 2021-10-05 | SouthendvEastleighNational League · England | 1–0 | National League · England |
| 2021-10-02 | SolihullvSouthendNational League · England | 2–0 | National League · England |
| 2021-09-18 | TorquayvSouthendNational League · England | 1–0 | National League · England |
| 2021-09-14 | SouthendvAldershotNational League · England | 2–3 | National League · England |
| 2021-09-11 | HalifaxvSouthendNational League · England | 3–1 | National League · England |
| 2021-09-04 | SouthendvWrexhamNational League · England | 2–2 | National League · England |
| 2021-08-30 | WealdstonevSouthendNational League · England | 0–0 | National League · England |
| 2021-08-28 | SouthendvStockportNational League · England | 0–1 | National League · England |
| 2021-08-21 | Kings LynnvSouthendNational League · England | 0–1 | National League · England |