| 2021-12-11 | HarrogatevNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2021-12-07 | ExetervNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2021-11-27 | NorthamptonvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-11-23 | NorthamptonvOldhamLeague Two · England | 2–1 | League Two · England |
| 2021-11-20 | BradfordvNorthamptonLeague Two · England | 1–1 | League Two · England |
| 2021-11-13 | Bristol RvsvNorthamptonLeague Two · England | 2–1 | League Two · England |
| 2021-10-30 | NorthamptonvCarlisleLeague Two · England | 3–0 | League Two · England |
| 2021-10-23 | TranmerevNorthamptonLeague Two · England | 0–2 | League Two · England |
| 2021-10-19 | NorthamptonvStevenageLeague Two · England | 3–0 | League Two · England |
| 2021-10-16 | NorthamptonvMansfieldLeague Two · England | 2–0 | League Two · England |
| 2021-10-09 | HartlepoolvNorthamptonLeague Two · England | 2–1 | League Two · England |
| 2021-10-02 | NorthamptonvSuttonLeague Two · England | 0–2 | League Two · England |
| 2021-09-25 | SalfordvNorthamptonLeague Two · England | 2–2 | League Two · England |
| 2021-09-18 | NorthamptonvSwindonLeague Two · England | 1–1 | League Two · England |
| 2021-09-14 | Newport CountyvNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2021-09-11 | Forest GreenvNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2021-09-04 | NorthamptonvScunthorpeLeague Two · England | 2–0 | League Two · England |
| 2021-08-28 | Crawley TownvNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2021-08-21 | NorthamptonvRochdaleLeague Two · England | 1–3 | League Two · England |
| 2021-08-14 | ColchestervNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2021-08-07 | NorthamptonvPort ValeLeague Two · England | 1–0 | League Two · England |