| 2025-12-29 | Milton Keynes DonsvNotts CountyLeague Two · England | 1–1 | League Two · England |
| 2025-12-26 | Milton Keynes DonsvSwindonLeague Two · England | 1–0 | League Two · England |
| 2025-12-20 | HarrogatevMilton Keynes DonsLeague Two · England | 0–4 | League Two · England |
| 2025-12-13 | Milton Keynes DonsvCambridgeLeague Two · England | 1–1 | League Two · England |
| 2025-12-09 | Notts CountyvMilton Keynes DonsLeague Two · England | 3–2 | League Two · England |
| 2025-11-29 | Milton Keynes DonsvFleetwood TownLeague Two · England | 2–1 | League Two · England |
| 2025-11-22 | TranmerevMilton Keynes DonsLeague Two · England | 2–2 | League Two · England |
| 2025-11-15 | Milton Keynes DonsvSalfordLeague Two · England | 2–0 | League Two · England |
| 2025-11-08 | BarnetvMilton Keynes DonsLeague Two · England | 2–2 | League Two · England |
| 2025-10-25 | BromleyvMilton Keynes DonsLeague Two · England | 2–1 | League Two · England |
| 2025-10-18 | Milton Keynes DonsvCreweLeague Two · England | 3–1 | League Two · England |
| 2025-10-11 | Bristol RvsvMilton Keynes DonsLeague Two · England | 0–4 | League Two · England |
| 2025-10-04 | Milton Keynes DonsvGillinghamLeague Two · England | 3–2 | League Two · England |
| 2025-09-27 | ShrewsburyvMilton Keynes DonsLeague Two · England | 1–2 | League Two · England |
| 2025-09-20 | Milton Keynes DonsvAccringtonLeague Two · England | 1–2 | League Two · England |
| 2025-09-13 | ChesterfieldvMilton Keynes DonsLeague Two · England | 1–1 | League Two · England |
| 2025-09-06 | Milton Keynes DonsvGrimsbyLeague Two · England | 2–3 | League Two · England |
| 2025-08-30 | Milton Keynes DonsvWalsallLeague Two · England | 0–1 | League Two · England |
| 2025-08-23 | Newport CountyvMilton Keynes DonsLeague Two · England | 1–2 | League Two · England |
| 2025-08-19 | Crawley TownvMilton Keynes DonsLeague Two · England | 1–1 | League Two · England |
| 2025-08-16 | Milton Keynes DonsvCheltenhamLeague Two · England | 5–0 | League Two · England |
| 2025-08-09 | BarrowvMilton Keynes DonsLeague Two · England | 0–2 | League Two · England |
| 2025-08-02 | Milton Keynes DonsvOldhamLeague Two · England | 0–0 | League Two · England |
| 2025-05-03 | SwindonvMilton Keynes DonsLeague Two · England | 0–0 | League Two · England |
| 2025-04-26 | Milton Keynes DonsvGrimsbyLeague Two · England | 0–0 | League Two · England |
| 2025-04-21 | CrewevMilton Keynes DonsLeague Two · England | 0–1 | League Two · England |
| 2025-04-18 | Milton Keynes DonsvNewport CountyLeague Two · England | 0–0 | League Two · England |
| 2025-04-12 | GillinghamvMilton Keynes DonsLeague Two · England | 1–0 | League Two · England |
| 2025-04-05 | Milton Keynes DonsvBarrowLeague Two · England | 0–3 | League Two · England |
| 2025-04-02 | Notts CountyvMilton Keynes DonsLeague Two · England | 3–0 | League Two · England |
| 2025-03-29 | Milton Keynes DonsvFleetwood TownLeague Two · England | 2–4 | League Two · England |
| 2025-03-25 | CarlislevMilton Keynes DonsLeague Two · England | 2–2 | League Two · England |
| 2025-03-22 | CheltenhamvMilton Keynes DonsLeague Two · England | 0–1 | League Two · England |
| 2025-03-15 | Port ValevMilton Keynes DonsLeague Two · England | 3–0 | League Two · England |
| 2025-03-08 | Milton Keynes DonsvMorecambeLeague Two · England | 2–1 | League Two · England |
| 2025-03-04 | AccringtonvMilton Keynes DonsLeague Two · England | 2–0 | League Two · England |
| 2025-03-01 | Milton Keynes DonsvColchesterLeague Two · England | 0–1 | League Two · England |
| 2025-02-22 | BradfordvMilton Keynes DonsLeague Two · England | 2–0 | League Two · England |
| 2025-02-15 | TranmerevMilton Keynes DonsLeague Two · England | 1–1 | League Two · England |
| 2025-02-11 | BarrowvMilton Keynes DonsLeague Two · England | 2–1 | League Two · England |
| 2025-02-08 | Milton Keynes DonsvBromleyLeague Two · England | 0–1 | League Two · England |
| 2025-02-01 | DoncastervMilton Keynes DonsLeague Two · England | 2–1 | League Two · England |
| 2025-01-28 | Milton Keynes DonsvHarrogateLeague Two · England | 2–1 | League Two · England |
| 2025-01-25 | Milton Keynes DonsvAFC WimbledonLeague Two · England | 0–0 | League Two · England |
| 2025-01-21 | Fleetwood TownvMilton Keynes DonsLeague Two · England | 2–1 | League Two · England |
| 2025-01-18 | WalsallvMilton Keynes DonsLeague Two · England | 4–2 | League Two · England |
| 2025-01-04 | Milton Keynes DonsvSalfordLeague Two · England | 0–1 | League Two · England |
| 2025-01-01 | ChesterfieldvMilton Keynes DonsLeague Two · England | 1–2 | League Two · England |