| 2021-12-26 | MansfieldvHartlepoolLeague Two · England | 3–2 | League Two · England |
| 2021-12-11 | HartlepoolvScunthorpeLeague Two · England | 0–0 | League Two · England |
| 2021-12-08 | HartlepoolvRochdaleLeague Two · England | 2–1 | League Two · England |
| 2021-11-27 | Port ValevHartlepoolLeague Two · England | 2–0 | League Two · England |
| 2021-11-23 | SwindonvHartlepoolLeague Two · England | 3–1 | League Two · England |
| 2021-11-20 | HartlepoolvForest GreenLeague Two · England | 1–3 | League Two · England |
| 2021-11-12 | HartlepoolvNewport CountyLeague Two · England | 1–2 | League Two · England |
| 2021-10-30 | Leyton OrientvHartlepoolLeague Two · England | 5–0 | League Two · England |
| 2021-10-23 | HartlepoolvHarrogateLeague Two · England | 3–2 | League Two · England |
| 2021-10-19 | BradfordvHartlepoolLeague Two · England | 1–3 | League Two · England |
| 2021-10-16 | SalfordvHartlepoolLeague Two · England | 2–0 | League Two · England |
| 2021-10-09 | HartlepoolvNorthamptonLeague Two · England | 2–1 | League Two · England |
| 2021-10-02 | StevenagevHartlepoolLeague Two · England | 2–0 | League Two · England |
| 2021-09-25 | HartlepoolvExeterLeague Two · England | 1–1 | League Two · England |
| 2021-09-18 | OldhamvHartlepoolLeague Two · England | 0–0 | League Two · England |
| 2021-09-14 | SuttonvHartlepoolLeague Two · England | 1–0 | League Two · England |
| 2021-09-11 | HartlepoolvBristol RvsLeague Two · England | 1–0 | League Two · England |
| 2021-09-04 | TranmerevHartlepoolLeague Two · England | 1–0 | League Two · England |
| 2021-08-28 | HartlepoolvCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-08-21 | HartlepoolvWalsallLeague Two · England | 2–0 | League Two · England |
| 2021-08-14 | BarrowvHartlepoolLeague Two · England | 3–2 | League Two · England |
| 2021-08-07 | HartlepoolvCrawley TownLeague Two · England | 1–0 | League Two · England |