| 2021-12-11 | StevenagevCarlisleLeague Two · England | 0–2 | League Two · England |
| 2021-12-07 | MansfieldvCarlisleLeague Two · England | 1–0 | League Two · England |
| 2021-11-27 | CarlislevWalsallLeague Two · England | 1–0 | League Two · England |
| 2021-11-23 | CarlislevHarrogateLeague Two · England | 0–2 | League Two · England |
| 2021-11-20 | ExetervCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-11-13 | CarlislevBarrowLeague Two · England | 0–0 | League Two · England |
| 2021-10-30 | NorthamptonvCarlisleLeague Two · England | 3–0 | League Two · England |
| 2021-10-23 | CarlislevOldhamLeague Two · England | 0–0 | League Two · England |
| 2021-10-19 | Newport CountyvCarlisleLeague Two · England | 2–2 | League Two · England |
| 2021-10-16 | CarlislevTranmereLeague Two · England | 0–1 | League Two · England |
| 2021-10-09 | Bristol RvsvCarlisleLeague Two · England | 3–0 | League Two · England |
| 2021-10-02 | CarlislevForest GreenLeague Two · England | 0–2 | League Two · England |
| 2021-09-25 | SuttonvCarlisleLeague Two · England | 4–0 | League Two · England |
| 2021-09-18 | CarlislevScunthorpeLeague Two · England | 2–2 | League Two · England |
| 2021-09-11 | Crawley TownvCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-09-04 | CarlislevSalfordLeague Two · England | 2–1 | League Two · England |
| 2021-08-28 | HartlepoolvCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-08-21 | CarlislevLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-08-17 | Port ValevCarlisleLeague Two · England | 0–0 | League Two · England |
| 2021-08-14 | SwindonvCarlisleLeague Two · England | 1–2 | League Two · England |
| 2021-08-07 | CarlislevColchesterLeague Two · England | 0–0 | League Two · England |
| 2021-05-08 | CarlislevWalsallLeague Two · England | 0–0 | League Two · England |
| 2021-05-01 | Leyton OrientvCarlisleLeague Two · England | 2–3 | League Two · England |
| 2021-04-27 | CheltenhamvCarlisleLeague Two · England | 1–1 | League Two · England |
| 2021-04-24 | CarlislevHarrogateLeague Two · England | 1–1 | League Two · England |
| 2021-04-20 | BoltonvCarlisleLeague Two · England | 1–0 | League Two · England |
| 2021-04-17 | CarlislevPort ValeLeague Two · England | 0–0 | League Two · England |
| 2021-04-13 | Newport CountyvCarlisleLeague Two · England | 0–0 | League Two · England |
| 2021-04-10 | BarrowvCarlisleLeague Two · England | 2–2 | League Two · England |
| 2021-04-06 | CarlislevScunthorpeLeague Two · England | 2–0 | League Two · England |
| 2021-04-03 | SouthendvCarlisleLeague Two · England | 0–2 | League Two · England |
| 2021-03-30 | CarlislevCrawley TownLeague Two · England | 2–0 | League Two · England |
| 2021-03-27 | CarlislevCambridgeLeague Two · England | 1–2 | League Two · England |
| 2021-03-23 | CarlislevLeyton OrientLeague Two · England | 0–1 | League Two · England |
| 2021-03-20 | StevenagevCarlisleLeague Two · England | 3–1 | League Two · England |
| 2021-03-16 | MansfieldvCarlisleLeague Two · England | 1–1 | League Two · England |
| 2021-03-13 | CarlislevBradfordLeague Two · England | 3–1 | League Two · England |
| 2021-03-09 | CarlislevGrimsbyLeague Two · England | 1–1 | League Two · England |
| 2021-03-06 | MorecambevCarlisleLeague Two · England | 3–1 | League Two · England |
| 2021-03-02 | ColchestervCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-02-27 | CarlislevOldhamLeague Two · England | 1–3 | League Two · England |
| 2021-02-23 | CarlislevTranmereLeague Two · England | 2–3 | League Two · England |
| 2021-02-20 | SalfordvCarlisleLeague Two · England | 1–1 | League Two · England |
| 2021-02-16 | HarrogatevCarlisleLeague Two · England | 1–0 | League Two · England |
| 2021-02-02 | CarlislevForest GreenLeague Two · England | 1–2 | League Two · England |
| 2021-01-30 | CarlislevExeterLeague Two · England | 1–0 | League Two · England |
| 2021-01-02 | WalsallvCarlisleLeague Two · England | 0–2 | League Two · England |